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    METHOD FOR PRODUCING MEANS PROTECTING AN ORGANISM AGAINST IONISING RADIATION
    2.
    发明公开
    METHOD FOR PRODUCING MEANS PROTECTING AN ORGANISM AGAINST IONISING RADIATION 有权
    用于生产的方式来保护有机体对电离辐射

    公开(公告)号：EP1864674A2

    公开(公告)日：2007-12-12

    申请号：EP06733214.8

    申请日：2006-02-17

    申请人： Rdinnovation APS

    发明人： SHIPOV, Valery Pavlovich ,  PIGAREV, Evgeny Sergeevich ,  FEDOROS, Elena Ivanovna ,  TROFIMOVA, Nadezhda Petrovna

    IPC分类号： A61K35/10 ,  A61K33/24 ,  A61P39/00

    CPC分类号： A61K36/00 ,  A61K33/24 ,  A61K35/10 ,  A61K2300/00

    摘要： The invention belongs to methods for production of preparations on the basis of humic substances for protection of the organism from ionizing radiations, and is efficient as a radioprotector and as a therapeutic drug to accelerate excretion of radionuclides and heavy metals from the affected organism.
    According to the method, an aqueous solution containing humic substances and ammonium molybdate is treated with wave radiation. The quantity of ammonium molybdate is up to 0.4 parts by weight per 1 part of humic substances. Irradiation with waves is conducted until the concentration of the high molecular weight humic substances is brought to a level of 5% or below.
    The wave radiation is selected in the ultrasonic frequency range from 18 kHz to 66 kHz, with irradiation power density from 0.5 to 5 W/cm 3 , or in the microwave frequency range. from 0.3 to 30 GHz, with irradiation power from 0.5 to 50 kW. For 5 W/cm 3 irradiation at the frequency of 2.45 GHz, the product being treated is maintained at the temperature of 60-70°C for 30 to 90 minutes. Humic substances are produced by oxidation of wood lignin.

    摘要翻译： 本发明属于生产的腐殖质用于从电离辐射保护有机体的基础上准备的方法，以及是有效率的作为无线电保护器和作为治疗药物，以加速放射性核素和重金属的排泄从受影响的生物体。 。根据该方法，在溶液wässrige含腐殖质和钼酸铵是治疗与波辐射。 钼酸铵的量是高达每腐殖质1份0.4重量份。 照射波被引导，直到所述高分子量腐殖物质的浓度带至5％或以下的水平。 波辐射在超声频率范围内选择18千赫至66千赫，用照射功率密度为0.5〜5W / cm 3时，或者在微波频率范围。 从0.3至30千兆赫，用照射功率为0.5至50千瓦。 5瓦/平方厘米在2.45GHz的频率3的照射下，所治疗的产品保持在60-70℃下进行30至90分钟时的温度。 腐殖质由木材木质素的氧化产生的。

    METHOD FOR PRODUCING AN ANTI-CANCER AGENT
    4.
    发明公开
    METHOD FOR PRODUCING AN ANTI-CANCER AGENT 有权
    VERFAHREN ZUR HERSTELLUNG EINES KREBSMITTELS

    公开(公告)号：EP1864673A2

    公开(公告)日：2007-12-12

    申请号：EP06733213.0

    申请日：2006-02-17

    申请人： Rdinnovation APS

    发明人： SHIPOV, Valery Pavlovich ,  PIGAREV, Evgeny Sergeevich ,  FEDOROS, Elena Ivanovna ,  TROFIMOVA, Nadezhda Petrovna

    IPC分类号： A61K35/10 ,  A61K33/24 ,  A61P35/00

    CPC分类号： A61K35/10 ,  A61K33/24 ,  A61K41/00 ,  A61K2300/00

    摘要： A method for producing an anti-cancer agent based on coordination compounds of platinum (II), under which an aqueous solution containing humic acids is treated with the said platinum compound.
    The coordination compound of platinum is selected from the following range: potassium tetrachloroplatinate, cis -dichlorodiammineplatinum, hydrogen tetrachloroplatinate, potassium tetrabromoplatinate. The treatment is conducted under irradiation with waves until the concentration of the high molecular fraction of humic substances is brought to a level of 5% or less.
    The wave radiation is selected from the ultrasonic range, with frequencies from 18 kHz to 66 kHz and power density from 0.5 to 4 W/cm 3 . For 5 W/cm 3 irradiation at the frequency of 22 kHz, the treatment is conducted for 5 to 20 minutes.
    Irradiation may also be performed with microwaves in the frequency range from 0.3 to 30 GHz and power from 0.5 to 50 kW. For 5 W/cm 3 irradiation at the frequency of 2.45 GHz, the product being treated is maintained at the temperature of 60-70°C for 30 to 90 minutes.

    摘要翻译： 一种基于铂（II）的配位化合物制备抗癌剂的方法，在该方法下，用所述铂化合物处理含有腐殖酸的水溶液。 铂配位化合物选自以下范围：四氯铂酸钾，顺二氯二氨基铂，四氯铂酸氢四钾，四溴铂酸钾。 用波浪照射进行处理，直到腐殖质的高分子量浓度达到5％以下。 波长辐射是从超声波范围中选出的，频率范围为18 kHz至66 kHz，功率密度为0.5至4 W / cm 3。 对于频率为22kHz的5W / cm 3的照射，进行5〜20分钟的处理。 也可以在0.3〜30GHz的频率范围内的微波和0.5〜50kW的功率下进行照射。 对于频率为2.45GHz的5W / cm 3照射，待处理的产品在60-70℃的温度下保持30-90分钟。