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公开(公告)号：EP4389746A3
公开(公告)日：2024-07-03
申请号：EP22215635.8
申请日：2022-12-21
发明人： GRAZIANI, Davide , RIVA, Carlo , PIRONA, Lorenza , MENEGON, Sergio , TAZZARI, Valerio , FRIGERIO, Fabio
IPC分类号： C07D471/04 , C07D487/04 , A61P25/02 , A61K31/5025
CPC分类号： C07D471/04 , C07D487/04 , A61P25/02
摘要： This invention relates to compounds of formula I;
and their use as antagonists of P2X3 and P2X2/3 receptor activity, pharmaceutical compositions comprising such compounds, and methods of treatment therewith. Compounds of the invention can be used for the treatment and/or prevention of pain and chronic pain and tolerance to analgesic, respiratory disorders and dysfunctions, and treatment of overactive bladder, bladder pain syndrome, dysuria and in general in genitourinary diseases, cardiovascular disorders and more in general for the potential treatment of visceral organ diseases and disorders characterized by the involvement of P2X3 and P2X2/3 receptors.-
公开(公告)号：EP3544584A1
公开(公告)日：2019-10-02
申请号：EP17800854.6
申请日：2017-11-20
发明人： BERLATI, Fabio , MENEGON, Sergio , FARINA, Pierluigi , PROVVEDINI, Diego , BARCHIELLI, Marco , MATTEI, Alberto
摘要： The present invention relates to a pharmaceutical formulation suitable for parenteral administration containing carglumic acid and a buffering agent having a pK a from 5.5 to 9.0 at 25°C; according to an embodiment, the buffering agent may have a pK a from 7.5 to 8.5, preferably a pK a of about 8.07, such as trometamol. The formulation may also contain at least one bulking agent, such as mannitol. The invention also includes a method for manufacturing a lyophilised sterile formulation by freeze-drying a water solution containing carglumic acid, a buffering agent having a pK a from 5.5 to 9.0 at 25°C, preferably from 7.5 to 8.5, and optionally a bulking agent to obtain a freeze-dried powder.
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公开(公告)号：EP4389746A2
公开(公告)日：2024-06-26
申请号：EP22215635.8
申请日：2022-12-21
发明人： GRAZIANI, Davide , RIVA, Carlo , PIRONA, Lorenza , MENEGON, Sergio , TAZZARI, Valerio , FRIGERIO, Fabio
IPC分类号： C07D471/04 , C07D487/04 , A61P25/02 , A61K31/5025
CPC分类号： C07D471/04 , C07D487/04 , A61P25/02
摘要： This invention relates to compounds of formula I;
and their use as antagonists of P2X3 and P2X2/3 receptor activity, pharmaceutical compositions comprising such compounds, and methods of treatment therewith. Compounds of the invention can be used for the treatment and/or prevention of pain and chronic pain and tolerance to analgesic, respiratory disorders and dysfunctions, and treatment of overactive bladder, bladder pain syndrome, dysuria and in general in genitourinary diseases, cardiovascular disorders and more in general for the potential treatment of visceral organ diseases and disorders characterized by the involvement of P2X3 and P2X2/3 receptors.-
公开(公告)号：EP3820566A1
公开(公告)日：2021-05-19
申请号：EP19748719.2
申请日：2019-07-11
IPC分类号： A61P25/04 , C07D471/14 , C07D487/14 , C07D491/22 , C07D519/00 , A61K31/4375 , A61K31/519
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