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1.发明公开
公开(公告)号：EP3954760A1
公开(公告)日：2022-02-16
申请号：EP20806297.6
申请日：2020-05-15
发明人： ZHANG, Ting
摘要： Provided are a clinical-grade autologous bronchial basal cell, a transfusion formulation thereof, and a preparation process. The preparation process comprises the following steps: extracting in vitro active bronchial brush biopsy tissue for digestive treatment, and collecting cells after digestion is terminated; performing plating culture on the digested cells by using a culture plate having trophoblast cells plated thereon, collecting cells, performing amplification culture on the digested cells by using a culture plate having trophoblast cells plated thereon, and when cells grow to cover 50%-90% of the surface area of the culture plate, performing secondary culture; and when secondary culture cells grow to cover 85%-95% of the surface area of a culture dish, digesting and collecting adhered cells, and washing. The prepared bronchial basal cell can be used for repairing damaged lung tissue.
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2.发明公开
公开(公告)号：EP4053263A1
公开(公告)日：2022-09-07
申请号：EP21842680.7
申请日：2021-07-14
发明人： ZHANG, Ting
摘要： The present invention provides a REGEND001 cell autologous deliverable formulation for use in improving the pulmonary function of a patient suffering from idiopathic pulmonary fibrosis. The preparation is prepared by collection, in vitro isolation and culture and amplification of the patient's autologous bronchial basal cells.
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