公开(公告)号：EP3056082A1

公开(公告)日：2016-08-17

申请号：EP16157878.6

申请日：2010-10-04

申请人： Regeneron Pharmaceuticals, Inc. ,  Yale University ,  Institute for Research in Biomedicine (IRB)

发明人： STEVENS, Sean ,  MURPHY, Andrew J. ,  FLAVELL, Richard ,  EYNON, Elizabeth ,  GALAN, Jorge ,  WILLINGER, Tim ,  MANZ, Markus, G. ,  RONGVAUX, Anthony ,  YANCOPOULOS, George D.

IPC分类号： A01K67/027 ,  C07K14/52 ,  C07K14/535 ,  C12N9/00 ,  C07K14/715 ,  C07K14/54 ,  A61K49/00

CPC分类号： A01K67/0278 ,  A01K67/0271 ,  A01K67/0275 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0331 ,  A01K2267/0337 ,  A01K2267/0381 ,  A01K2267/0387 ,  A61K49/00 ,  C07K14/524 ,  C07K14/535 ,  C07K14/5403 ,  C07K14/7155 ,  C12N9/00

摘要： A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mII2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a yeloproliferative neoplasia.

摘要翻译： 具有mIL-3基因和mGM-CSF基因的人源化的小鼠，mRAG基因的敲除和mII2rg亚基基因的敲除; 并且可选地描述了TPO基因的人源化。 描述了RAG / II2rg KO / hTPO敲入小鼠。 描述了维持人类免疫细胞（HIC）群体的人类造血干细胞（HSCs）的小鼠，所述人类免疫细胞（HIC）群体衍生自HSC并且可被人类病原体例如伤寒沙门氏菌或结核分枝杆菌感染。 描述了模拟在小鼠中模拟不良的人类病原体感染的小鼠，例如模拟人类分枝杆菌感染的小鼠，其中小鼠产生包含人免疫细胞的一种或多种肉芽肿。 描述了包含源于早期人类造血细胞的人类造血恶性肿瘤的小鼠，例如骨髓性白血病或叶绿体增生性肿瘤。

公开(公告)号：EP2485583B1

公开(公告)日：2016-07-06

申请号：EP10822486.6

申请日：2010-10-04

申请人： REGENERON PHARMACEUTICALS, INC. ,  Yale University ,  Institute for Research in Biomedicine (IRB)

发明人： STEVENS, Sean ,  MURPHY, Andrew J. ,  FLAVELL, Richard ,  EYNON, Elizabeth ,  GALAN, Jorge ,  WILLINGER, Tim ,  MANZ, Markus, G. ,  RONGVAUX, Anthony ,  YANCOPOULOS, George D.

IPC分类号： A01K67/027 ,  C07K14/52 ,  C07K14/535 ,  C07K14/715 ,  C12N9/00 ,  C07K14/54 ,  A61K49/00

CPC分类号： A01K67/0278 ,  A01K67/0271 ,  A01K67/0275 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0331 ,  A01K2267/0337 ,  A01K2267/0381 ,  A01K2267/0387 ,  A61K49/00 ,  C07K14/524 ,  C07K14/535 ,  C07K14/5403 ,  C07K14/7155 ,  C12N9/00

摘要： A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mII2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a yeloproliferative neoplasia.

公开(公告)号：EP2485583A2

公开(公告)日：2012-08-15

申请号：EP10822486.6

申请日：2010-10-04

申请人： REGENERON PHARMACEUTICALS, INC. ,  Yale University ,  Institute for Research in Biomedicine (IRB)

发明人： STEVENS, Sean ,  MURPHY, Andrew J. ,  FLAVELL, Richard ,  EYNON, Elizabeth ,  GALAN, Jorge ,  WILLINGER, Tim ,  MANZ, Markus ,  RONGVAUX, Anthony

IPC分类号： A01K67/027 ,  A01K49/00

CPC分类号： A01K67/0278 ,  A01K67/0271 ,  A01K67/0275 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0331 ,  A01K2267/0337 ,  A01K2267/0381 ,  A01K2267/0387 ,  A61K49/00 ,  C07K14/524 ,  C07K14/535 ,  C07K14/5403 ,  C07K14/7155 ,  C12N9/00

摘要： A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mII2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a yeloproliferative neoplasia.

公开(公告)号：EP4049535A1

公开(公告)日：2022-08-31

申请号：EP21214150.1

申请日：2010-10-04

申请人： Regeneron Pharmaceuticals, Inc. ,  Yale University ,  Institute for Research in Biomedicine (IRB)

发明人： STEVENS, Sean ,  MURPHY, Andrew J. ,  FLAVELL, Richard ,  EYNON, Elizabeth ,  GALAN, Jorge ,  WILLINGER, Tim ,  MANZ, Markus, G. ,  RONGVAUX, Anthony ,  YANCOPOULOS, George D.

IPC分类号： A01K67/027 ,  C07K14/52 ,  C07K14/535 ,  C12N9/00 ,  C07K14/715 ,  C07K14/54

摘要： A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mll2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modelled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic dells is described, e.g., a myeloid leukemia or a myeloproliferative neoplasia.

公开(公告)号：EP3417701A1

公开(公告)日：2018-12-26

申请号：EP18183928.3

申请日：2010-10-04

申请人： Regeneron Pharmaceuticals, Inc. ,  Yale University ,  Institute for Research in Biomedicine (IRB)

发明人： STEVENS, Sean ,  MURPHY, Andrew J. ,  FLAVELL, Richard ,  EYNON, Elizabeth ,  GALAN, Jorge ,  WILLINGER, Tim ,  MANZ, Markus, G. ,  RONGVAUX, Anthony ,  YANCOPOULOS, George D.

IPC分类号： A01K67/027 ,  C07K14/52 ,  C07K14/535 ,  C12N9/00 ,  C07K14/715 ,  C07K14/54 ,  A61K49/00

CPC分类号： A01K67/0278 ,  A01K67/0271 ,  A01K67/0275 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0331 ,  A01K2267/0337 ,  A01K2267/0381 ,  A01K2267/0387 ,  A61K49/00 ,  C07K14/524 ,  C07K14/535 ,  C07K14/5403 ,  C07K14/7155 ,  C12N9/00

摘要： A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mll2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modelled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic dells is described, e.g., a myeloid leukemia or a myeloproliferative neoplasia.

公开(公告)号：EP3056082B1

公开(公告)日：2018-09-05

申请号：EP16157878.6

申请日：2010-10-04

申请人： Regeneron Pharmaceuticals, Inc. ,  Yale University ,  Institute for Research in Biomedicine (IRB)

发明人： STEVENS, Sean ,  MURPHY, Andrew J. ,  FLAVELL, Richard ,  EYNON, Elizabeth ,  GALAN, Jorge ,  WILLINGER, Tim ,  MANZ, Markus, G. ,  RONGVAUX, Anthony ,  YANCOPOULOS, George D.

IPC分类号： A01K67/027 ,  C07K14/52 ,  C07K14/535 ,  C12N9/00 ,  C07K14/715 ,  C07K14/54 ,  A61K49/00

CPC分类号： A01K67/0278 ,  A01K67/0271 ,  A01K67/0275 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0331 ,  A01K2267/0337 ,  A01K2267/0381 ,  A01K2267/0387 ,  A61K49/00 ,  C07K14/524 ,  C07K14/535 ,  C07K14/5403 ,  C07K14/7155 ,  C12N9/00

摘要： A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mII2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a yeloproliferative neoplasia.