公开(公告)号：EP2550292B1

公开(公告)日：2017-11-22

申请号：EP11760135.1

申请日：2011-03-23

申请人： Research Development Foundation ,  Arbovax Inc.

发明人： BROWN, Dennis, T. ,  HERNANDEZ, Raquel ,  THOMAS, Malcolm, E. ,  SMITH, Katherine, M. ,  NANDA, Kavita

IPC分类号： C07K14/18 ,  C12N15/40 ,  C12N7/01 ,  A61K39/12 ,  A61P31/14

CPC分类号： C12N7/00 ,  A61K39/12 ,  C12N2770/24134 ,  C12N2770/24161 ,  C12N2770/24162 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/394 ,  Y02A50/396

摘要： Methods and compositions concerning mutant flaviviruses with host range mutations. In some embodiments the invention concerns nucleotide sequences that encode mutant flavivirus proteins. Viruses comprising these sequences that display reduced replication in mammalian cells are provided. In further aspects of the invention, flavivirus vaccine compositions are provided. In another embodiment the invention provides methods for vaccination against flavivirus infection.

公开(公告)号：EP2550292A2

公开(公告)日：2013-01-30

申请号：EP11760135.1

申请日：2011-03-23

申请人： Research Development Foundation ,  Arbovax Inc.

发明人： BROWN, Dennis, T. ,  HERNANDEZ, Raquel ,  THOMAS, Malcolm, E. ,  SMITH, Katherine, M. ,  NANDA, Kavita

IPC分类号： C07K14/18 ,  C12N15/40 ,  C12N7/01 ,  A61K39/12 ,  A61P31/14

CPC分类号： C12N7/00 ,  A61K39/12 ,  C12N2770/24134 ,  C12N2770/24161 ,  C12N2770/24162 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/394 ,  Y02A50/396

摘要： Methods and compositions concerning mutant flaviviruses with host range mutations. In some embodiments the invention concerns nucleotide sequences that encode mutant flavivirus proteins. Viruses comprising these sequences that display reduced replication in mammalian cells are provided. In further aspects of the invention, flavivirus vaccine compositions are provided. In another embodiment the invention provides methods for vaccination against flavivirus infection.