公开(公告)号：EP1500401A1

公开(公告)日：2005-01-26

申请号：EP03717687.2

申请日：2003-04-22

申请人： Research Foundation Itsuu Laboratory

发明人： NAGAI, Ryozo ,  SHINDO, Takayuki ,  MANABE, Ichiro ,  SHUDO, Koichi ,  KAGECHIKA, Hiroyuki

IPC分类号： A61K45/00 ,  A61K31/27 ,  A61K31/695 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P43/00

CPC分类号： A61K31/27 ,  A61K31/695 ,  A61L31/16

摘要： A medicament for prophylactic and/or therapeutic treatment of a vascular disease such as vascular restenosis and/or reocclusion after percutaneous transluminal coronary angioplasty using an intravascular stent, which comprises as an active ingredient a substance selected from the group consisting of retinoids and agents for controlling actions of retinoids such as 4-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or a salt thereof, or 4-[[[3,5-bis-(trimethylsilyl)phenyl]carbonyl]amino]benzoic acid or a salt thereof, wherein said substance has substantially no antiproliferative action on vascular endothelial cells, but substantially has antiproliferative action on vascular smooth muscle cells.

摘要翻译： 一种用于在使用血管内支架的经皮腔内冠状动脉血管成形术之后进行血管疾病如血管再狭窄和/或再闭塞的预防和/或治疗性治疗药物，其包含选自维甲酸类和控制剂的活性成分 类维生素A 4,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基苯甲酸或其盐或4-哒嗪-3,5-双（三甲基甲硅烷基） 苯基羰基氨基苯甲酸或其盐，其中所述物质对血管内皮细胞基本上没有抗增殖作用，但对血管平滑肌细胞基本具有抗增殖作用。