专利检索 ap:("Resolution Chemicals Limited") AND inv:"Gamble, Mark" 第 1 页

1.

发明授权
Preparation of cabergoline form I und solvate thereof 无效
标题翻译：一种用于制备卡麦角林和溶剂化物的晶体形式I其过程

公开(公告)号：EP1591445B1

公开(公告)日：2008-05-07

申请号：EP05252709.0

申请日：2005-04-29

申请人： Resolution Chemicals Limited

发明人： Greenwood, Alan , McHattie, Derek , Bhatarah, Parveen , Gamble, Mark

IPC分类号： C07D457/06

CPC分类号： C07D457/06

2.

发明公开
Preparation of cabergoline form I und solvate therof 无效
标题翻译：一种用于制备卡麦角林和溶剂化物的晶体形式I其过程

公开(公告)号：EP1591445A1

公开(公告)日：2005-11-02

申请号：EP05252709.0

申请日：2005-04-29

申请人： Resolution Chemicals Limited

发明人： Greenwood, Alan , McHattie, Derek , Bhatarah, Parveen , Gamble, Mark

IPC分类号： C07D457/06

CPC分类号： C07D457/06

摘要： The present invention discloses a method for preparing cabergoline form I by combining cabergoline and a solvent comprising ethylbenzene to form a solvate and obtaining form I from the solvate. Also disclosed in a method for preparing cabergoline form I by combining cabergoline and a first solvent to form a solution and additionally including a second solvent to the solution, followed by crystallization to form cabergoline form I. Further disclosed is a solvate form of cabergoline comprising cabergoline and ethylbenzene and, optionally, n-heptane.