专利检索 ap:("Rhodes Technologies Inc.") AND inv:"HUNTLEY, C. Frederick M." 第 1 页

1.

发明公开
ACETATE SALT OF BUPRENORPHINE AND METHODS FOR PREPARING BUPRENORPHINE 审中-公开
标题翻译：丁丙诺啡的醋酸盐及制备丁丙诺啡的方法

公开(公告)号：EP3283490A1

公开(公告)日：2018-02-21

申请号：EP16709607.2

申请日：2016-03-09

申请人： Rhodes Technologies Inc.

发明人： HUNTLEY, C. Frederick M. , KATAISTO, Erik Wayne , REISCH, Helge Alfred , SHARMA, Archana , STYMIEST, Jake Larry

IPC分类号： C07D489/12 , A61K31/485 , A61P25/04

CPC分类号： A61K31/485 , A61P25/04 , C07B2200/13 , C07D489/12

摘要： The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.