公开(公告)号：EP2173761B1

公开(公告)日：2013-04-10

申请号：EP08776244.9

申请日：2008-06-30

申请人： Richter Gedeon Nyrt.

发明人： OLASZ, Katalin ,  TEGDES, Aniko ,  GANCSOS, Valéria ,  HANTOS, Gabor ,  KÖNCZÖL, Kalman ,  BALOGH, Gabor ,  ERDELYI, Sandor

IPC分类号： C07J21/00

CPC分类号： C07J21/003

公开(公告)号：EP2173761A2

公开(公告)日：2010-04-14

申请号：EP08776244.9

申请日：2008-06-30

申请人： Richter Gedeon Nyrt.

发明人： OLASZ, Katalin ,  TEGDES, Aniko ,  GANCSOS, Valéria ,  HANTOS, Gabor ,  KÖNCZÖL, Kalman ,  BALOGH, Gabor ,  ERDELYI, Sandor

IPC分类号： C07J21/00

CPC分类号： C07J21/003

摘要： The present invention relates to a novel selective synthesis of 9α-hydroxy-steroid derivatives of the general formula (I) (I) - wherein the meaning of -A-A'- is -CH
2 -CH
2 - or -CH=CH- group - by the bioconversion of compounds of the general formula (II) (II) wherein the meaning of -A-A'- is -CH
2 -CH
2 - or -CH=CH- group - by using Nocardia farcinica bacterium strain, deposition number of which is NCAIM (P) - B 001342, as hydroxylating microorganism in the bioconversion.