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公开(公告)号：EP2074083B1
公开(公告)日：2013-06-19
申请号：EP07824996.8
申请日：2007-10-27
申请人： Richter Gedeon Nyrt.
发明人： BOZÓ, Éva , BEKE, Gyula , ÉLES, János , FARKAS, Sándor , HORNOK, Katalin , KESERÜ, György , SCHMIDT, Éva , SZENTIRMAY, Éva , VÁGÓ, István , VASTAG, Mónika
IPC分类号： C07C311/21 , A61K31/18 , A61P29/00 , C07D207/26 , C07D211/18 , C07D211/56 , C07D211/62 , C07D211/76 , C07D213/38 , C07D213/72 , C07D233/54 , C07D239/04 , C07D239/42 , C07D241/20 , C07D243/08 , C07D295/12 , C07D295/20 , C07D401/04 , C07D401/06 , C07D401/12
CPC分类号： C07C311/21 , C07D207/26 , C07D211/26 , C07D211/34 , C07D211/56 , C07D211/62 , C07D211/76 , C07D213/38 , C07D213/74 , C07D213/75 , C07D233/54 , C07D239/04 , C07D239/42 , C07D241/20 , C07D243/08 , C07D295/12 , C07D295/20 , C07D401/04 , C07D401/06 , C07D401/12
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公开(公告)号：EP2074083A1
公开(公告)日：2009-07-01
申请号：EP07824996.8
申请日：2007-10-27
申请人： Richter Gedeon Nyrt.
发明人： BOZÓ, Éva , BEKE, Gyula , ÉLES, János , FARKAS, Sándor , HORNOK, Katalin , KESERÜ, György , SCHMIDT, Éva , SZENTIRMAY, Éva , VÁGÓ, István , VASTAG, Mónika
IPC分类号： C07C311/21 , A61K31/18 , A61P29/00 , C07D207/26 , C07D211/26 , C07D211/34 , C07D211/56 , C07D211/62 , C07D211/76 , C07D213/38 , C07D213/74 , C07D213/75 , C07D233/54 , C07D239/04 , C07D239/42
CPC分类号： C07C311/21 , C07D207/26 , C07D211/26 , C07D211/34 , C07D211/56 , C07D211/62 , C07D211/76 , C07D213/38 , C07D213/74 , C07D213/75 , C07D233/54 , C07D239/04 , C07D239/42 , C07D241/20 , C07D243/08 , C07D295/12 , C07D295/20 , C07D401/04 , C07D401/06 , C07D401/12
摘要： The present invention relates to new sulfonamide derivatives of formula (I), wherein R1 -R5 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these compounds, pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.
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3.发明公开NEW PHENYLSULFAMOYL BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS 有权新的苯基氨基磺酰基苯甲酰胺衍生物作为BRADYKININ ANTAGONISTS
公开(公告)号：EP2057116A1
公开(公告)日：2009-05-13
申请号：EP07824995.0
申请日：2007-10-27
申请人： Richter Gedeon Nyrt.
发明人： BEKE, Gyula , BOZÓ, Éva , FARKAS, Sándor , HORNOK, Katalin , KESERÜ, György , SCHMIDT, Éva , SZENTIRMAY, Éva , VÁGÓ, István , VASTAG, Mónika
IPC分类号： C07C311/21 , A61K31/18 , A61P29/00 , C07D209/08 , C07D211/26 , C07D211/58 , C07D213/40 , C07D231/40 , C07D233/54 , C07D235/30 , C07D261/14 , C07D277/46 , C07D277/62 , C07D277/82 , C07D285/12
CPC分类号： C07C311/21 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D209/08 , C07D211/26 , C07D211/58 , C07D213/40 , C07D213/75 , C07D231/40 , C07D233/54 , C07D233/64 , C07D235/30 , C07D241/08 , C07D261/14 , C07D277/46 , C07D277/62 , C07D277/82 , C07D285/135 , C07D295/13 , C07D295/135 , C07D317/46
摘要： The present invention relates to new sulfonamide derivatives of formula (I), wherein R1-R8 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these same compounds, pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.
摘要翻译： 本发明涉及式（I）的新型磺酰胺衍生物，其中R1-R8和Z如权利要求中所定义，以及作为选择性拮抗剂的光学对映体或外消旋体和/或盐和/或水合物和/或溶剂合物 缓激肽B1，制备这些相同化合物的方法，含有它们的药物组合物，以及它们在治疗或预防疼痛和炎症状况中的用途。
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公开(公告)号：EP2076491B1
公开(公告)日：2013-07-17
申请号：EP07824994.3
申请日：2007-10-27
申请人： Richter Gedeon Nyrt.
发明人： VÁGÓ, István , BEKE, Gyula , BOZÓ, Éva , FARKAS, Sándor , HORNOK, Katalin , KESERÜ, György , SCHMIDT, Éva , SZENTIRMAY, Éva , VASTAG, Mónika
IPC分类号： C07D207/08 , A61K31/18 , A61P29/00 , C07D207/26 , C07D211/06 , C07D211/68 , C07D219/06 , C07D223/10 , C07D239/42 , C07D241/06 , C07D241/20 , C07D243/08 , C07D279/12 , C07D295/16 , C07D295/26 , C07D307/14 , C07D307/04 , C07D401/06 , C07D487/08 , C07K5/06
CPC分类号： C07D295/185 , C07D207/08 , C07D207/26 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/44 , C07D211/58 , C07D211/62 , C07D211/68 , C07D211/76 , C07D219/06 , C07D223/10 , C07D239/42 , C07D241/06 , C07D241/20 , C07D243/08 , C07D279/12 , C07D295/20 , C07D295/26 , C07D307/14 , C07D307/24 , C07D307/68 , C07D401/06 , C07D487/08
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公开(公告)号：EP1966142A2
公开(公告)日：2008-09-10
申请号：EP06831519.1
申请日：2006-12-19
申请人： Richter Gedeon NYRT
发明人： BEKE, Gyula , BOZÓ, Éva , CZÍRA, Gábor , ÉLES, János , FARKAS, Sándor , HORNOK, Katalin , SCHMIDT, Éva , SZENTIRMAY, Éva , VÁGÓ, István , VASTAG, Mónika
IPC分类号： C07D213/74 , C07D221/12 , C07D295/12 , C07D401/10 , C07D401/12 , C07D401/14 , A61K31/473 , A61P25/02
CPC分类号： C07D401/12 , C07D213/74 , C07D221/12 , C07D295/135 , C07D401/10 , C07D401/14
摘要： The present invention relates to new phenanthridine derivatives of formula (I), wherein the variables are as defined in the specificition, to processes for producing the same, to pharmacological compositions containing the same and to their use in therapy or prevention of painful and inflammatory processes.
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公开(公告)号：EP2057116B1
公开(公告)日：2013-02-13
申请号：EP07824995.0
申请日：2007-10-27
申请人： Richter Gedeon Nyrt.
发明人： BEKE, Gyula , BOZÓ, Éva , FARKAS, Sándor , HORNOK, Katalin , KESERÜ, György , SCHMIDT, Éva , SZENTIRMAY, Éva , VÁGÓ, István , VASTAG, Mónika
IPC分类号： C07C311/21 , A61K31/18 , A61P29/00 , C07D209/08 , C07D211/26 , C07D211/58 , C07D213/40 , C07D213/75 , C07D231/40 , C07D233/54 , C07D235/30 , C07D241/08 , C07D261/14 , C07D277/46 , C07D277/62 , C07D277/82 , C07D285/135 , C07D295/12 , C07D317/46 , C07K5/06
CPC分类号： C07C311/21 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D209/08 , C07D211/26 , C07D211/58 , C07D213/40 , C07D213/75 , C07D231/40 , C07D233/54 , C07D233/64 , C07D235/30 , C07D241/08 , C07D261/14 , C07D277/46 , C07D277/62 , C07D277/82 , C07D285/135 , C07D295/13 , C07D295/135 , C07D317/46
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公开(公告)号：EP2215055A1
公开(公告)日：2010-08-11
申请号：EP07824993.5
申请日：2007-10-27
申请人： Richter Gedeon Nyrt.
发明人： VÁGÓ, István , FARKAS, Sándor , HORNOK, Katalin , BEKE, Gyula , BOZÓ, Éva , VASTAG, Mónika , SZENTIRMAY, Éva , KESERÜ, György , SCHMIDT, Éva
IPC分类号： C07C311/21 , A61K31/18 , A61P29/00 , C07D207/12 , C07D211/22 , C07D211/26 , C07D211/44 , C07D211/58 , C07D211/62 , C07D241/06 , C07D243/08 , C07D279/12 , C07D295/20 , C07D401/04
CPC分类号： C07C311/21 , C07D207/36 , C07D211/22 , C07D211/26 , C07D211/46 , C07D211/58 , C07D211/60 , C07D211/74 , C07D241/08 , C07D295/096 , C07D295/185
摘要： The present invention relates to new non-peptide derivatives of formula (I), wherein R
1 -R
5 , Q and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these compounds, to pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.-
公开(公告)号：EP2076491A1
公开(公告)日：2009-07-08
申请号：EP07824994.3
申请日：2007-10-27
申请人： Richter Gedeon Nyrt.
发明人： VÁGÓ, István , BEKE, Gyula , BOZÓ, Éva , FARKAS, Sándor , HORNOK, Katalin , KESERÜ, György , SCHMIDT, Éva , SZENTIRMAY, Éva , VASTAG, Mónika
IPC分类号： C07D207/08 , A61K31/18 , A61P29/00 , C07D207/26 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/44 , C07D211/58 , C07D211/62 , C07D211/68 , C07D211/76 , C07D219/06
CPC分类号： C07D295/185 , C07D207/08 , C07D207/26 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/44 , C07D211/58 , C07D211/62 , C07D211/68 , C07D211/76 , C07D219/06 , C07D223/10 , C07D239/42 , C07D241/06 , C07D241/20 , C07D243/08 , C07D279/12 , C07D295/20 , C07D295/26 , C07D307/14 , C07D307/24 , C07D307/68 , C07D401/06 , C07D487/08
摘要： The present invention relates to new phenylsulfamoyl benzamide derivatives of formula (I), wherein R1-R5 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these compounds, to pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.
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