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    Method for purifying teriparatide (PTH1-34)
    1.
    发明公开
    Method for purifying teriparatide (PTH1-34) 有权
    Verfahren zur Reinigung von Teriparatid（PTH1-34）

    公开(公告)号：EP2905289A1

    公开(公告)日：2015-08-12

    申请号：EP14154713.3

    申请日：2014-02-11

    申请人： Richter-Helm Bio Tec GmbH & Co. KG

    发明人： Reich, Christoph ,  Kuechler, Martin

    IPC分类号： C07K14/635 ,  C07K1/18

    CPC分类号： C07K1/18 ,  C07K14/635

    摘要： The present invention relates to a novel method for purifying teriparatide, a therapeutically active polypeptide fragment of full-length human parathyroid hormone. The method is based on ion exchange chromatography and is effective in separating the therapeutically active polypeptide from undesirable variants, such as truncated polypeptides. The method of the invention can be used at a preparative scale which allows it to be implemented into the production process for teriparatide. Accordingly, the invention also provides a method for the production of teriparatide which includes a step in which teriparatide is purified by the novel ion exchange chromatography method of the invention.

    摘要翻译： 本发明涉及纯化特立帕肽的全新方法，其是全长人甲状旁腺激素的治疗​​活性多肽片段。 该方法基于离子交换层析，并且有效地将治疗活性多肽与不期望的变体如截短的多肽分离。 本发明的方法可以以制备规模使用，其允许其实施为特立帕肽的生产过程。 因此，本发明还提供了一种制备特立帕肽的方法，其包括通过本发明的新型离子交换色谱法纯化特立帕肽的步骤。