公开(公告)号：EP1656372A2

公开(公告)日：2006-05-17

申请号：EP04786150.5

申请日：2004-07-30

申请人： Rigel Pharmaceuticals, Inc.

发明人： RAJINDER, Singh ,  ANKUSH, Argade ,  LI, Hui ,  BHAMIDIPATI, Somasekhar ,  CARROLL, David ,  SYLVAIN, Catherine ,  CLOUGH, Jeffrey ,  KEIM, Holger

IPC分类号： C07D413/14

CPC分类号： C07D498/04 ,  A61K31/506 ,  A61K31/541 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D498/06

摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.

摘要翻译： 本发明提供用2,4-嘧啶二胺化合物治疗或预防自身免疫疾病的方法，以及治疗，预防或改善与这些疾病相关的症状的方法。 可以用化合物治疗或预防的自身免疫性疾病的具体实例包括类风湿性关节炎和/或其相关症状，系统性红斑狼疮和/或其相关症状和多发性硬化症和/或其相关症状。

公开(公告)号：EP1656372B1

公开(公告)日：2013-04-10

申请号：EP04786150.5

申请日：2004-07-30

申请人： Rigel Pharmaceuticals, Inc.

发明人： RAJINDER, Singh ,  ANKUSH, Argade ,  LI, Hui ,  BHAMIDIPATI, Somasekhar ,  CARROLL, David ,  SYLVAIN, Catherine ,  CLOUGH, Jeffrey ,  KEIM, Holger

IPC分类号： C07D413/14

CPC分类号： C07D498/04 ,  A61K31/506 ,  A61K31/541 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D498/06

摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.