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公开(公告)号：EP3532470A1
公开(公告)日：2019-09-04
申请号：EP17797495.3
申请日：2017-10-25
发明人： LI, Hui , HECKRODT, Thilo , CHEN, Yan , KELLEY, Ryan , MCMURTRIE, Darren , TSO, Kin , TAYLOR, Vanessa , SINGH, Rajinder , YEN, Rose , MAUNG, Jack
IPC分类号： C07D413/14 , A61P29/00 , A61K31/422
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公开(公告)号：EP2928891B1
公开(公告)日：2019-02-20
申请号：EP13812297.3
申请日：2013-12-03
发明人： MCMURTRIE, Darren , KOLLURI, Rao , MASUDA, Esteban , TSO, Kin , ALVAREZ, Salvador , HECKRODT, Thilo , HOLLAND, Sacha , KELLEY, Ryan , DUNCTON, Matthew , SINGH, Rajinder
IPC分类号： C07D455/02
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公开(公告)号：EP2370415B1
公开(公告)日：2016-04-20
申请号：EP09835863.3
申请日：2009-12-23
发明人： BHAMIDIPATI, Somasekhar , LI, Hui , SINGH, Rajinder , TAYLOR, Vanessa , CLOUGH, Jeffrey , MCMURTRIE, Darren
IPC分类号： A61K31/505 , A61P37/06 , C07D239/48
CPC分类号： C07D239/48
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4.发明公开
公开(公告)号：EP2928891A1
公开(公告)日：2015-10-14
申请号：EP13812297.3
申请日：2013-12-03
发明人： MCMURTRIE, Darren , KOLLURI, Rao , MASUDA, Esteban , TSO, Kin , ALVAREZ, Salvador , HECKRODT, Thilo , HOLLAND, Sacha , KELLEY, Ryan , DUNCTON, Matthew , SINGH, Rajinder
IPC分类号： C07D455/02
CPC分类号： A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , C07D455/02 , C07D498/04
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions that include these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本公开涉及可用作蛋白激酶C（PKC）的抑制剂的化合物，因此可用于治疗通过PKC的活性介导或维持的多种疾病和病症。 本公开还涉及包括这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：EP2382210B1
公开(公告)日：2017-03-01
申请号：EP09837134.7
申请日：2009-12-29
发明人： SINGH, Rajinder , ATUEGBU, Andy , RAMPHAL, John , LI, Hui , GELMAN, Marina , CLOUGH, Jeffrey , VALDEZ, Carlos , BHAMIDIPATI, Somasekhar , THOTA, Sambaiah , MCMURTRIE, Darren
IPC分类号： C07D413/14 , A61K31/506 , A61P35/00 , C07D413/12 , C07D417/12 , C07D498/04 , C07D487/08
CPC分类号： A61K31/5383 , A61K45/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/08 , C07D498/04
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公开(公告)号：EP2382210A2
公开(公告)日：2011-11-02
申请号：EP09837134.7
申请日：2009-12-29
发明人： SINGH, Rajinder , ATUEGBU, Andy , RAMPHAL, John , LI, Hui , GELMAN, Marina , CLOUGH, Jeffrey , VALDEZ, Carlos , BHAMIDIPATI, Somasekhar , THOTA, Sambaiah , MCMURTRIE, Darren
IPC分类号： C07D413/14
CPC分类号： A61K31/5383 , A61K45/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/08 , C07D498/04
摘要： The present invention provides pyrimidinediamine compounds useful for inhibiting kinase activity, including the activity of polo-like kinase 1 (PLK1). Also provided are pharmaceutical compositions comprising these compounds and methods of treating diseases associated with kinase activity, in particular enhanced PLK1 catalytic activity, such as diseases associated with abnormal cell proliferation, including neoplastic disorders.
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公开(公告)号：EP2370415A2
公开(公告)日：2011-10-05
申请号：EP09835863.3
申请日：2009-12-23
发明人： BHAMIDIPATI, Somasekhar , LI, Hui , SINGH, Rajinder , TAYLOR, Vanessa , CLOUGH, Jeffrey , MCMURTRIE, Darren
IPC分类号： C07D239/22 , A61K31/505 , A61P37/06
CPC分类号： C07D239/48
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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