公开(公告)号：EP1781704A2

公开(公告)日：2007-05-09

申请号：EP05778628.7

申请日：2005-08-01

申请人： Rinat Neuroscience Corp.

发明人： ROSENTHAL, Arnon ,  PONS, Jaume ,  HO, Wei-Hsien ,  GRIMM, Jan, Markus

IPC分类号： C07K16/18

CPC分类号： C07K16/18 ,  A61K39/00 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

摘要： Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer's disease and Aβ peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer's disease and Aβ peptide associated diseases are also described.

摘要翻译： 单克隆抗体9TL和抗体从9TL衍生针对β-淀粉样蛋白肽，并使用相同的用于诊断和治疗阿尔茨海默病和A 2的方法; 肽相关的疾病中有描述。 使用针对淀粉样蛋白β肽具有用于治疗阿尔茨海默氏病和A 2的受损的效应子功能的抗体的方法; 肽相关的疾病是这样描述的。