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1.发明公开
公开(公告)号：EP1519192A3
公开(公告)日：2005-06-08
申请号：EP04022393.5
申请日：2004-09-21
发明人： Sigler, Gerald F. , Hui, Raymond A. , Deras, Ina , Root, Richard Terry , Ghoshal, Mitali , Huber, Erasmus , Von der Eltz, Herbert , Metz, Sigrun , Kern, Peter
IPC分类号： G01N33/53 , C07K16/38 , C07D401/12 , C07D493/04 , C12N5/16
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for HIV protease inhibitors. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group common to all HIV protease inhibitors, e.g., saquinavir, nelfinavir, indinavir, amprenavir, ritonavir, lopinavir, and atazanavir.
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2.发明公开HIV Protease inhibitor conjugates and antibodies useful in ummunoassay 审中-公开艾滋病病毒蛋白酶抑制剂联合免疫抑制剂ZUR VERWENDUNG IM IMMUNOASSAY
公开(公告)号：EP1519192A2
公开(公告)日：2005-03-30
申请号：EP04022393.5
申请日：2004-09-21
发明人： Sigler, Gerald F. , Hui, Raymond A. , Deras, Ina , Root, Richard Terry , Ghoshal, Mitali , Huber, Erasmus , Von der Eltz, Herbert , Metz, Sigrun , Kern, Peter
IPC分类号： G01N33/53 , C07K16/38 , C07D401/12 , C07D493/04 , C12N5/16
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for HIV protease inhibitors. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group common to all HIV protease inhibitors, e.g., saquinavir, nelfinavir, indinavir, amprenavir, ritonavir, lopinavir, and atazanavir.
摘要翻译： 可用于产生HIV蛋白酶抑制剂免疫原的活化半抗原，可用于产生HIV蛋白酶抑制剂抗体的免疫原，以及可用于HIV蛋白酶抑制剂免疫测定的抗体和标记结合物。 所述新型半抗原在所有HIV蛋白酶抑制剂（例如沙奎那韦，奈非那韦，茚地那韦，安格那韦，利托那韦，洛匹那韦和阿扎那韦）共同的中心非末端羟基上具有活化的功能。
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