公开(公告)号：EP2882458B1

公开(公告)日：2018-07-11

申请号：EP13745844.4

申请日：2013-08-07

申请人： Roche Glycart AG

发明人： HOSSE, Ralf ,  KLEIN, Christian ,  MOESSNER, Ekkehard ,  PETERSON, Laurence Bernard ,  UMANA, Pablo ,  WICKER, Linda

IPC分类号： A61K51/10 ,  A61K38/20 ,  C07K14/55 ,  C12N15/62

CPC分类号： C07K14/55 ,  A61K38/2013 ,  C07K16/18 ,  C07K16/46 ,  C07K2317/21 ,  C07K2319/00 ,  C07K2319/30

摘要： The present invention generally relates to fusion proteins of immunoglobulins and interleukin-2 (IL-2). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the fusion proteins of the invention, and to methods of using them in the treatment of disease.

公开(公告)号：EP2882458A1

公开(公告)日：2015-06-17

申请号：EP13745844.4

申请日：2013-08-07

申请人： Roche Glycart AG

发明人： HOSSE, Ralf ,  KLEIN, Christian ,  MOESSNER, Ekkehard ,  PETERSON, Laurence Bernard ,  UMANA, Pablo ,  WICKER, Linda

IPC分类号： A61K47/48 ,  A61K51/10 ,  A61K38/20 ,  C07K14/55 ,  C12N15/62

CPC分类号： C07K14/55 ,  A61K38/2013 ,  C07K16/18 ,  C07K16/46 ,  C07K2317/21 ,  C07K2319/00 ,  C07K2319/30

摘要： The present invention generally relates to fusion proteins of immunoglobulins and interleukin-2 (IL-2). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the fusion proteins of the invention, and to methods of using them in the treatment of disease.

摘要翻译： 本发明一般涉及免疫球蛋白和白细胞介素-2（IL-2）的融合蛋白。 此外，本发明涉及编码这种融合蛋白的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。 本发明进一步涉及本发明的融合蛋白的制备方法及其在疾病治疗中的应用。