公开(公告)号：EP3882616A1

公开(公告)日：2021-09-22

申请号：EP21160955.7

申请日：2017-02-09

申请人： Roswell Biotechnologies, Inc

发明人： CHOI, Chulmin ,  JIN, Sungho ,  MOLA, Paul, W. ,  MERRIMAN, Barry L.

IPC分类号： G01N27/327

摘要： A method of manufacturing a device useable in DNA or genome sequencing comprises disposing pairs of electrodes (49) on a substrate, the electrodes within each pair separated by a nanogap; depositing a resist layer (48) over the electrodes (49); patterning the resist layer (48) to create an exposed region (44) on each electrode (49) at or near each nanogap; roughening the electrode surface within each exposed region using various methods; and exposing the exposed regions to biomolecules (42), wherein one biomolecule (42) bridges each nanogap of each electrode pair, with each end of each biomolecule (42) bound to the electrodes (49) at each exposed region (44).