公开(公告)号：EP2114377B1

公开(公告)日：2018-10-17

申请号：EP08728780.1

申请日：2008-01-31

申请人： Rutgers, The State University of New Jersey

发明人： KOHN, Joachim, B. ,  MICHNIAK, Bozena ,  DEVORE, David ,  SHEIHET, Larisa ,  CHANDRA, Prafulla ,  BATHEJA, Priya

IPC分类号： A61K8/90 ,  A61K9/06 ,  A61K9/70 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/04

CPC分类号： A61K9/0014 ,  A61K8/90 ,  A61K9/5153 ,  A61K2800/412 ,  A61K2800/413 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/04 ,  B82Y5/00 ,  Y02A50/401

摘要： Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer; and the hydrophobic middle B block is a hydrophobic polymer or oligomer with the same or different repeating units having the structure according to formula:(I) wherein X is —C(=O)—R—C(=O)— or —C(=O)—; Z is between 2 and about 100, inclusive; R1 is CH=CH or (CH2)n, wherein n is from 0 to 18, inclusive; R2 is selected from hydrogen and straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms; and R is selected from a bond or straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms.

公开(公告)号：EP2114377A2

公开(公告)日：2009-11-11

申请号：EP08728780.1

申请日：2008-01-31

申请人： Rutgers, The State University of New Jersey

发明人： KOHN, Joachim, B. ,  MICHNIAK, Bozena ,  DEVORE, David ,  SHEIHET, Larisa ,  CHANDRA, Prafulla ,  BATHEJA, Priya

IPC分类号： A61K9/14

CPC分类号： A61K9/0014 ,  A61K8/90 ,  A61K9/5153 ,  A61K2800/412 ,  A61K2800/413 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/04 ,  B82Y5/00 ,  Y02A50/401

摘要： Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer; and the hydrophobic middle B block is a hydrophobic polymer or oligomer with the same or different repeating units having the structure according to formula:(I) wherein X is —C(=O)—R—C(=O)— or —C(=O)—; Z is between 2 and about 100, inclusive; R1 is CH=CH or (CH2)n, wherein n is from 0 to 18, inclusive; R2 is selected from hydrogen and straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms; and R is selected from a bond or straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms.