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1.发明公开Polyester type polyfunctional macromonomer, gel and drug release controlling material responsive to changes in temperature 失效多官能大分子单体的聚酯凝胶，并用依赖于温度波动递送活性成分的物质。
公开(公告)号：EP0556818A1
公开(公告)日：1993-08-25
申请号：EP93102542.3
申请日：1993-02-18
发明人： Nagase, Yu , Aoyagi, Takao , Miyata, Fusae
摘要： A polyester type polyfunctional macromonomer represented by the general formula (I):
wherein R¹ represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms, X represents a hydrogen atom, a halogen atom, a cyano group, an alkyl group having from 1 to 6 carbon atoms or a phenyl group, A represents an aliphatic polyester chain, m is 0 or 1, and p, which may be the same or different in each branched chains, represents an integer of from 0 to 6; a polyester type gel which is obtained by polymerization of the polyester type polyfunctional macromonomer; and a drug release controlling material responsive to changes in temperature comprising the polyester type gel are disclosed. The polyester type gel possesses mechanical properties suitable to various utilities, in particular, as a biodegradable polymeric material having a high tensile elongation. The drug release controlling material has an on-off control function of drug release responsive to changes in temperature depending upon the gel transition of the aliphatic polyester type gel.摘要翻译： 由通式（I）表示的聚酯类的多官能大分子单体：
其中，R <1>表示氢原子或烷基具有1至6个碳原子基团，X表示氢原子，卤原子，氰基 基烷基具有1至6个碳原子或苯基，A darstellt到脂肪族聚酯链，m是0或1，且p，这可能是在每个支链的相同或不同的，darstellt到的从整数组 0至6; 聚酯类凝胶所有这是由聚酯型大分子单体的多官能的聚合而得到; 以及响应于温度，包括聚酯类凝胶的变化的药物释放控制材料是游离缺失盘。 聚酯类凝胶具有适合于各种用途的机械性能，特别是，作为具有高的拉伸伸长率的可生物降解的聚合物材料。 该药物释放控制材料具有药物释放响应于温度，这取决于脂肪族聚酯类凝胶的凝胶转变的变化的开 - 关控制功能。
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