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公开(公告)号：EP0834497B1
公开(公告)日：2001-10-24
申请号：EP96918834.1
申请日：1996-06-19
发明人： HIRAI, Kenji , MASUDA, Katsuyuki , TAKAO, Yoshihiro , SUGIYAMA, Masahide , ONO, Yukio , MATSUZAWA, Masahumi
IPC分类号： C07C69/65 , C07C67/30 , C07D311/76 , C07C67/307
CPC分类号： C07D311/76 , C07C67/24 , C07C69/65
摘要： A process for efficiently and conveniently producing 2-(halomethyl)phenylacetic acid esters (3), which are useful as intermediates in the production of agricultural insecticides, by reacting a 3-isochromanone derivative (1) with a hydrogen halide and an alcohol or a dihalomethyl alkyl ether followed by the reaction with an alcohol (2) in the presence of a base. The starting 3-isochromanone derivative (1) can be produced in a high yield by reacting an α,α'-o-xylylene dihalide derivative (4) with carbon monoxide and water in the presence of a palladium catalyst and an inorganic base in an organic solvent and subsequently treating with an acid.
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公开(公告)号：EP0834497A1
公开(公告)日：1998-04-08
申请号：EP96918834.1
申请日：1996-06-19
发明人： HIRAI, Kenji , MASUDA, Katsuyuki , TAKAO, Yoshihiro , SUGIYAMA, Masahide , ONO, Yukio , MATSUZAWA, Masahumi
IPC分类号： C07C69/65 , C07C67/30 , C07D311/76
CPC分类号： C07D311/76 , C07C67/24 , C07C69/65
摘要： 2-(Halomethyl)phenylacetic acid esters (3) which are useful as intermediates for producing agricultural fungicides are produced efficiently and conveniently by reacting a 3-isochromanone derivative (1) with a hydrogen halide and an alcohol or reacting (1) with a halomethyl alkyl ether and then reacting the product with an alcohol in the presence of a base. The starting compound, 3-isochromanone (1), is produced in good yield by reacting an α,α'-o-xylene dihalide (4) with carbon monoxide and water in an organic solvent in the presence of a palladium catalyst and an inorganic base and then treating the product with an acid.
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