公开(公告)号：EP0622074A1

公开(公告)日：1994-11-02

申请号：EP94106236.6

申请日：1994-04-21

申请人： SAITAMA DAIICHI PHARMACEUTICAL CO., LTD. ,  DAIICHI PHARMACEUTICAL CO., LTD.

发明人： Takayasu, Toshiyuki, Saitama Daiichi Phar. Co. Ltd ,  Saitoh, Hideo, Saitama Daiichi Phar. Co. Ltd. ,  Mafune, Eiichi, c/o Daiichi Phar. Co. Ltd.,

IPC分类号： A61K9/70 ,  A61K31/445

CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61K31/435 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  Y10S514/949

摘要： A butyrophenone transdermal composition which comprises the following components (a) to (f):

(a) a water-soluble polymer which is constituted by a monomer containing, partly or wholly, aliphatic carboxylic acid having a polymerizable double bond or a salt of the carboxylic acid,
(b) a cross linking agent,
(c) a cross linking promoter,
(d) water,
(e) a butyrophenone drug, and
(f) a solvent for the butyrophenone drug (e),
as essential components. The pH of the composition is adjusted to fall in the range of 5.5 to 8.0.
With the composition of the invention, the concentration of the active component butyrophenone in blood can be controlled. The composition is capable of exhibiting its primary action, antiemetic action, without causing rash in the skin and with less adverse side effects.

摘要翻译： 一种丁酰苯酚透皮组合物，其包含以下组分（a）至（f）：（a）水溶性聚合物，其由含有部分或全部具有可聚合双键的脂肪族羧酸的单体或 羧酸，（b）交联剂，（c）交联促进剂，（d）水，（e）丁酰苯酮药物和（f）丁酰苯胺药物（e）的溶剂作为必需组分。 将组合物的pH调节至5.5〜8.0的范围。 利用本发明的组合物，可以控制血液中活性成分丁酰苯的浓度。 该组合物能够表现出其主要作用，止吐作用，而不会在皮肤中引起皮疹并且具有较少的副作用。