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公开(公告)号：EP1208092A1
公开(公告)日：2002-05-29
申请号：EP01922101.9
申请日：2001-04-07
发明人： PARK, Young-Jun , BAE, Hae-Young , YOO, Ji-Uk , CHAE, Myeong-Yun , PAEK, Sang-Hyun , MIN, Hye-Kyung , PARK, Hyun-Gyu , RYU, Choon-Ho , KIM, Kyung-Chul , LEE, Jeoung-Wook
IPC分类号： C07D277/68 , C07D263/58 , A61K31/423
CPC分类号： C07D417/12 , C07D277/74
摘要： The present invention provides a novel sulfonamide derivative of general formula (I) useful as an inhibitor of matrix metalloproteinase (MMP), its isomers, pharmaceutically acceptable salts thereof and a process for preparing the same. Since the sulfonamide derivatives of the present invention selectively inhibit MMP activity in vitro, the MMP inhibitors comprising the sulfonamide derivatives as an effective ingredient can be practically applied for the prevention and treatment of all sorts of diseases caused by overexpression and overactivation of MMP.
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公开(公告)号：EP1208092B1
公开(公告)日：2006-06-21
申请号：EP01922101.9
申请日：2001-04-07
发明人： PARK, Young-Jun , BAE, Hae-Young , YOO, Ji-Uk , CHAE, Myeong-Yun , PAEK, Sang-Hyun , MIN, Hye-Kyung , PARK, Hyun-Gyu , RYU, Choon-Ho , KIM, Kyung-Chul , LEE, Jeoung-Wook
IPC分类号： A61K31/423 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/5377 , A61K31/541 , C07D263/58 , C07D277/74 , C07D413/12 , C07D417/12 , A61P19/00 , A61P19/10 , A61P35/04
CPC分类号： C07D417/12 , C07D277/74
摘要： The present invention provides a novel sulfonamide derivative of general formula (I) useful as an inhibitor of matrix metalloproteinase (MMP), its isomers, pharmaceutically acceptable salts thereof and a process for preparing the same. Since the sulfonamide derivatives of the present invention selectively inhibit MMP activity in vitro, the MMP inhibitors comprising the sulfonamide derivatives as an effective ingredient can be practically applied for the prevention and treatment of all sorts of diseases caused by overexpression and overactivation of MMP.
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3.发明公开BIPHENYL BUTYRIC ACID DERIVATIVE AS A MATRIX METALLOPROTEINASE INHIBITOR 审中-公开BIPHENYL-BUTANSÄURE-DERIVATE ALS INHIBITOREN DER MATRIX-METALLOPROTEINASE
公开(公告)号：EP1189882A1
公开(公告)日：2002-03-27
申请号：EP01926225.2
申请日：2001-04-24
发明人： PARK, Young-Jun , RYU, Choon-Ho , YOO, Ji-Uk , CHAE, Myeong-Yun , PAEK, Sang-Hyun , KIM, Kyung-Chul , LEE, Jeoung-Wook , MIN, Hye-Kyung , BAE, Hae-Young , OH, Eu-Gene
IPC分类号： C07D207/00
CPC分类号： C07D295/185 , C07C235/78 , C07C237/22 , C07C237/42 , C07C255/60 , C07C2601/02 , C07D207/16 , C07D217/26 , C07D295/192 , C07D317/60
摘要： The present invention provides a novel biphenyl butyric acid derivative, isomer and pharmaceutically acceptable salts thereof which are useful as an inhibitor of matrix metalloproteinase (MMP) and a process for preparing the same. Since the biphenyl butyric acid derivative of the invention selectively inhibits the activity of MMP in vitro, it can be practically applied to the treatment and prevention of diseases caused by overexpression of MMP.
摘要翻译： 本发明提供了可用作基质金属蛋白酶（MMP）抑制剂的新型联苯基丁酸衍生物，其异构体和药学上可接受的盐及其制备方法。 由于本发明的联苯基丁酸衍生物在体外选择性地抑制MMP的活性，因此可以实际应用于治疗和预防由MMP的过度表达引起的疾病。
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