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1.
公开(公告)号:EP1149068A4
公开(公告)日:2003-01-02
申请号:EP00902170
申请日:2000-01-24
发明人: ROH KYOUNG ROK , YU HO SUNG , KIM KYUNG IL , LEE WON JANG , HWANG DAE IL
IPC分类号: C07C253/30 , C07B53/00 , C07C253/00 , C07C255/20 , C07C253/16
CPC分类号: C07C253/00 , C07B2200/07 , C07C255/20
摘要: The present invention relates to a process for preparing (R)-4-cyano-3-hydroxybutyric acid ester derivatives and more particularly, to a process for preparing optically pure (R)-4-cyano-3-hydroxybutyric acid ester derivatives expressed by formula (1) in high yield by performing cyanation and sequential esterification of (S)-3,4-epoxybutyric acid salt as a starting material. In said formula, R represents linear or branched alkyl group with 1∩5 carbon atoms or benzyl group.