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    AFFINITY LIGANDS
    2.
    发明公开
    AFFINITY LIGANDS 有权
    AFFINITÄTSLIGANDEN

    公开(公告)号：EP1874825A2

    公开(公告)日：2008-01-09

    申请号：EP06721225.8

    申请日：2006-04-25

    申请人： SANDOZ AG ,  Boehringer Ingelheim Austria GmbH

    发明人： JUNGBAUER, Alois ,  HAHN, Rainer ,  KAAR, Waltraud ,  SEIFERT, Michael ,  AUER, Bernhard ,  ACHMÜLLER, Clemens ,  WECHNER, Philipp

    IPC分类号： C07K17/06 ,  C07K1/22

    CPC分类号： C12P21/02 ,  C07K1/22 ,  C07K17/06 ,  C12N9/506 ,  C12N15/62

    摘要： Disclosed is an affinity matrix comprising a solid phase and an affinity ligand comprising peptide bonds coupled to this solid phase, wherein the affinity ligand comprising peptide bond is selected from the following group of ligands: a) peptides comprising the formula X1X2X3X4, wherein X1 to X4 are amino acid residues and at least two of X1 to X4 is W, Y or F; b) peptides comprising the formula X5X6X7X8, wherein X5 to X8 are amino acid residues, at least one of X5 to X8 is W, and at least one of X5 to X8 is E or D; and c) poly-amino acids consisting of an amino acid monomer of the group consisting of R, K, E and D and an amino acid monomer of the group consisting of Y, F and W, preferably poly-KY, poly-KF, poly-KW, poly-RY, poly-RF, poly-RW, poly-EY, poly-DY, poly-EF, poly-EW, poly-DF and poly-DW, with the proviso that the peptides according to a) and b) have a maximum length of 35 amino acid residues and that the poly-amino acids according to c) have a minimum length of 20 amino acid residues.