公开(公告)号：EP0885891A4

公开(公告)日：2001-02-21

申请号：EP97903623

申请日：1997-02-27

申请人： SANKYO CO

发明人： KOJIMA KOICHI ,  SAKAI JUNICHI ,  SAMATA NAOZUMI ,  KOZUKA MASAO ,  YOSHIMI KENJI ,  KANEKO TSUGIO

IPC分类号： A61K31/42 ,  A61K31/422 ,  A61P25/16 ,  A61P25/28 ,  C07D261/10 ,  C07D261/12 ,  C07D413/04 ,  C07D417/04 ,  A61K31/425

CPC分类号： C07D413/04 ,  C07D261/12

摘要： Isoxazole derivatives represented by general formula (I), which have an excellent monoamine oxidase inhibitory activity and are useful for the treatment or prevention of nervous diseases such as depression, wherein R1 represents optionally substituted aryl or optionally substituted heteroaryl; R2 represents hydrogen, halogeno, optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, alkoxy, cyano, carboxy, alkanoyl, alkoxycarbonyl, or optionally substituted carbamoyl; R3 represents optionally substituted amino or saturated heterocyclic group; X represents oxygen or sulfur; and n is an integer of 2 to 6.

公开(公告)号：EP0779281A4

公开(公告)日：2000-07-26

申请号：EP95929249

申请日：1995-08-29

申请人： SANKYO CO

发明人： KOJIMA KOICHI ,  AIZAWA YUICHI ,  KANEKO ISAO ,  SAKAI JUNICHI ,  KOZUKA MASAO ,  KOYAMA KAZUO ,  SAMATA NAOZUMI ,  YOSHIMI KENJI

IPC分类号： A61K31/42 ,  A61K31/423 ,  A61K31/424 ,  A61K31/44 ,  A61P25/16 ,  A61P25/24 ,  A61P25/28 ,  C07D261/20 ,  C07D498/02 ,  C07D498/04 ,  A61K31/425 ,  A61K31/435 ,  A61K31/495

CPC分类号： C07D261/20

摘要： An isoxazole derivative represented by general formula (I), having an excellent monoamine oxidase inhibitory activity, and being useful as a remedy or preventive for nervous diseases such as Parkinson's diseases, wherein R1 represents hydrogen, halogen, alkyl, alkoxy, hydroxy, alkylthio, amino, alkanoyl, alkanoylamino, alkanoyloxy, alkoxycarbonyl, carboxy, (alkylthio)-thiocarbonyl, carbamoyl, nitro or cyano; R2 represents amino; m represents an integer of 1 to 3; n represents an integer of 1 to 6; ring A represents benzene, naphthalene or aromatic heterocycle; and X represents oxygen or sulfur.