公开(公告)号：EP2078009A1

公开(公告)日：2009-07-15

申请号：EP07858463.8

申请日：2007-10-17

申请人： Sanofi-Aventis

发明人： THOMPSON, Fabienne ,  MAILLIET, Patrick ,  RUXER, Jean-Marie ,  GOULAOUIC, Hélène ,  VALLEE, François ,  MINOUX, Hervé ,  PILORGE, Fabienne ,  BERTIN, Luc ,  HOURCADE, Stéphane ,  MENDEZ-PEREZ, Maria ,  HAMLEY, Peter

IPC分类号： C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61K31/437 ,  A61K31/506 ,  A61P25/16 ,  A61P25/28 ,  A61P35/00

CPC分类号： C07D403/12 ,  C07D401/12 ,  C07D471/04 ,  C07D487/04

摘要： The invention relates to new products of the formula (I) in which: Het is an optionally substituted mono- or bicyclic heterocycle containing 1 to 4 heteroatoms selected from N, O or S; R1 is X-(A-B)n-CONH2, X-(A-B)n-O-CONH2, X-(A-B)n-NH-CONH2, X-(CH2)m-heterocycloalkyl, X-(CH2)m-aryl and X-(CH2)m-heteroaryl with X being -O-C(O), -NH-C(O), NH-CS, -NH-CO-CH2-O-; -NH-CO-CH2-S-CH2-CO-NH-; -NH-CO-(CH2)2-SO2-; -NH-CO-CH2-N(CH3)-CO-; A and B represent a simple bond, CH2, CH-alkyl, CH-aralkyl, n = 1,2 and m = 0, 1; R2 and R'2 represent H, halogen, CF3, nitro, cyano, alkyl, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, alkylthio, carboxy free or esterified by an alkyl, carboxamide, CO-NH(alkyl) and NH-CO-alkyl radical; p= 1 to 4 and p'= 1 to 3; L represents a simple bond, CH2, C(O), O, S or NH, all said radicals being optionally substituted. The invention also relates to all the isomeric forms of the products and the salts thereof used as drugs.

公开(公告)号：EP2078009B1

公开(公告)日：2015-03-18

申请号：EP07858463.8

申请日：2007-10-17

申请人： SANOFI

发明人： THOMPSON, Fabienne ,  MAILLIET, Patrick ,  RUXER, Jean-Marie ,  GOULAOUIC, Hélène ,  VALLEE, François ,  MINOUX, Hervé ,  PILORGE, Fabienne ,  BERTIN, Luc ,  HOURCADE, Stéphane ,  MENDEZ-PEREZ, Maria ,  HAMLEY, Peter

IPC分类号： C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61K31/437 ,  A61K31/506 ,  A61P25/16 ,  A61P25/28 ,  A61P35/00

CPC分类号： C07D403/12 ,  C07D401/12 ,  C07D471/04 ,  C07D487/04