公开(公告)号：EP1458721A1

公开(公告)日：2004-09-22

申请号：EP02796852.8

申请日：2002-11-20

申请人： SANOFI-SYNTHELABO

发明人： BURNIER, Philippe ,  FROISSANT, Jacques ,  MARABOUT, Benoît ,  MARGUET, Frank ,  PUECH, Frédéric

IPC分类号： C07D487/04 ,  A61K31/50 ,  A61P25/02 ,  A61P25/28

CPC分类号： C07D487/04 ,  C07D209/42

摘要： The invention concerns compounds of general formula (I), wherein: X represents a hydrogen or halogen atom; R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 and R3, represent each, independently of each other, a hydrogen atom or a (C1-C4)alkyl group, or R2 and R3 form, with the atom which bears them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl, pyridazinyl type, the heteroaromatic group may represent one or several halogen atoms and/or one or several (C1-C4)alkyl, (C1-C4)alkoxyl groups; in the form of bases, addition salts to acids, solvates or hydrates. The invention also concerns pharmaceutical compositions containing same, methods for preparing same and synthesis intermediates.