公开(公告)号：EP1725235B1

公开(公告)日：2009-04-15

申请号：EP05712200.4

申请日：2005-02-02

申请人： Schering Corporation

发明人： TING, Pauline C. ,  CAO, Jianhua ,  DONG, Youhao ,  GILBERT, Eric J. ,  HUANG, Ying ,  KELLY, Joseph M. ,  MCCOMBIE, Stuart ,  SHIH, Neng-Yang

IPC分类号： A61K31/4709 ,  A61K31/444 ,  A61P11/06 ,  C07D401/04 ,  C07D401/14

CPC分类号： C07D401/14 ,  C07D211/18 ,  C07D211/58 ,  C07D401/04 ,  C07D471/04

摘要： The use of CCR3 antagonists of the formula (I) or a pharmaceutically acceptable salt thereof for the treatment of asthma is disclosed, as well as novel compounds of the formula (II), pharmaceutical compositions comprising them, and their use in the treatment of asthma, wherein R, Ra, X, Xa, R1, R2, R2a, R14, R14a, R16 and n are as defined in the specification.

公开(公告)号：EP1725235A1

公开(公告)日：2006-11-29

申请号：EP05712200.4

申请日：2005-02-02

申请人： SCHERING CORPORATION

发明人： TING, Pauline C. ,  CAO, Jianhua ,  DONG, Youhao ,  GILBERT, Eric J. ,  HUANG, Ying ,  KELLY, Joseph M. ,  MCCOMBIE, Stuart ,  SHIH, Neng-Yang

IPC分类号： A61K31/4709 ,  A61K31/444 ,  A61P11/06 ,  C07D401/04 ,  C07D401/14

CPC分类号： C07D401/14 ,  C07D211/18 ,  C07D211/58 ,  C07D401/04 ,  C07D471/04

摘要： The use of CCR3 antagonists of the formula (I) or a pharmaceutically acceptable salt thereof for the treatment of asthma is disclosed, as well as novel compounds of the formula (II), pharmaceutical compositions comprising them, and their use in the treatment of asthma, wherein R, Ra, X, Xa, R1, R2, R2a, R14, R14a, R16 and n are as defined in the specification.