公开(公告)号：EP1524524A1

公开(公告)日：2005-04-20

申请号：EP04012655.9

申请日：1999-12-15

申请人： SCIOS INC.

发明人： Joly, Alison ,  Schreiner, George, F. ,  Stanton, Lawrence, W. ,  White, R., Tyler ,  Damm, Deborah, L. ,  Lewicki, John, A.

IPC分类号： G01N33/68 ,  C12Q1/68 ,  C07K14/475

CPC分类号： C07K14/475 ,  C12Q1/6883 ,  C12Q2600/158

摘要： The present invention relates to methods and compositions for the detection, diagnosis, prevention and treatment of a disease, specifically cardiac, kidney or inflammatory disease, and related disorders. The present invention also relates to compositions and methods useful in the diagnosis, prevention and therapeutic treatment of a disease, specifically cardiac, kidney or inflammatory disease. Specifically, methods and compositions are provided for the diagnostic evaluation and prognosis of conditions involving a disease, specifically cardiac, kidney or inflammatory disease, for the identification of subjects exhibiting a predisposition to such conditions, for modulating the effect of these differentially expressed genes, for monitoring patients undergoing clinical evaluation for the prevention and treatment of a disease, specifically cardiac, kidney or inflammatory disease, and its disorders, and for monitoring the efficacy of compounds used in clinical trials.

摘要翻译： 本发明涉及用于检测，诊断，预防和治疗疾病，特别是心脏，肾脏或炎症疾病以及相关疾病的方法和组合物。 本发明还涉及用于诊断，预防和治疗疾病，特别是心脏，肾脏或炎性疾病的组合物和方法。 具体地，提供方法和组合物用于诊断评估和涉及疾病，特别是心脏，肾脏或炎性疾病的病症，用于鉴定表现出对这些病症倾向的受试者，用于调节这些差异表达基因的作用，用于 监测接受临床评估的患者，预防和治疗疾病，特别是心脏，肾脏或炎症疾病及其疾病，并监测临床试验中使用的化合物的功效。