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    Tuftsin analogues and vaccines containing these as adjuvants
    8.
    发明公开
    Tuftsin analogues and vaccines containing these as adjuvants 失效
    Tuftsin-Analoge und Impfstoffe，die diese Analoge als Adjuvantien enthalten。

    公开(公告)号：EP0392095A2

    公开(公告)日：1990-10-17

    申请号：EP89201371.5

    申请日：1989-05-30

    申请人： SCLAVO S.p.A.

    发明人： Nencioni, Luciano ,  Pileri, Piero ,  Peppoloni, Samuele ,  Silvestri, Sergio

    IPC分类号： C07K5/02 ,  A61K39/39

    CPC分类号： C07K5/0212 ,  A61K39/00

    摘要： The invention is concerned with compounds analogous to tuftsin, having the formula (I)
    or of a pharmaceutically acceptable base-addition or acid-addition salt thereof, and the use of them in vaccines as an adjuvant in order to potentiate, in a living organism, the antibody response against either natural or synthetic antigens, as well as with the novel compositions for vaccines which comprise one or more of said antigens together with an adjuvating amount of the compound of formula (I) or of one of its addition salts.

    摘要翻译： 本发明涉及类似于具有式（I）或其药学上可接受的碱加成或酸加成盐的簇绒蛋白的化合物，以及它们在疫苗中作为佐剂的用途，以加强， 生物体，针对天然或合成抗原的抗体应答，以及包含一种或多种所述抗原与佐剂量的式（I）化合物或其加成物之一的疫苗的新型组合物 盐。

    New retro-inverso analogues of trymopentin, the method for their synthesis and their use in the preparation of pharmaceutical compositions
    9.
    发明公开
    New retro-inverso analogues of trymopentin, the method for their synthesis and their use in the preparation of pharmaceutical compositions 失效
    逆反Thrymopentin类似物，它们的制备方法和它们的药物组合物的制备中的用途。

    公开(公告)号：EP0375058A2

    公开(公告)日：1990-06-27

    申请号：EP89203230.1

    申请日：1989-12-18

    申请人： SCLAVO S.p.A.

    发明人： Mariotti, Sabina ,  Sisto, Alessandro ,  Nencioni, Luciano ,  Villa, Luigi ,  Verdini, Antonio Silvio

    IPC分类号： C07K5/02 ,  C07K7/02

    CPC分类号： C07K5/0212 ,  A61K38/00 ,  C07K7/02

    摘要： New analogues of thymopentin (TP5) and of its tetrapeptide fragment (TP5¹⁻⁴) containing two non-contiguous retro-inverted bonds in the peptide chain are described.
    The new compounds, of general formula (I)
    where R is hydrogen or an acyl radical,
    and R¹ is an -OR² group or an
    group where R² is a hydrogen atom or a hydrocarbon radical, and R³ is a hydrogen atom or a hydroxyl group,
    and the corresponding pharmaceutically acceptable salts of acid or basic addition, possess immunomodulating activity.

    摘要翻译： 胸腺五肽（TP5）的新类似物及其四肽片段（TP5 <1> < - > <4>）包含在该肽链中的两个不相邻的逆转化的键的描述。 这些新化合物的通式（I）其中R是氢或基团的酰基，且R <1>，为-OR <2>基或团，其中R <2>是氢原子 或烃基，且R <3>是氢原子或羟基，和相应的酸或碱加成的药学上可接受的盐，具有免疫调节活性。