公开(公告)号：EP2956441A4

公开(公告)日：2016-11-02

申请号：EP14751923

申请日：2014-02-18

申请人： SCRIPPS RESEARCH INST

发明人： ROBERTS EDWARD ,  MITTAPALLI GOPI KUMAR ,  WANG YUANHUA ,  YANG JUN ,  TOUSSAINT MARION ,  HABAROVA OLGA ,  ROSEN HUGH

IPC分类号： C07D229/02

CPC分类号： C07D491/107 ,  C07D207/16 ,  C07D211/62 ,  C07D213/74 ,  C07D235/30 ,  C07D239/42 ,  C07D239/94 ,  C07D241/44 ,  C07D241/54 ,  C07D249/08 ,  C07D263/58 ,  C07D267/20 ,  C07D277/82 ,  C07D295/20 ,  C07D295/205 ,  C07D307/14 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/14 ,  C07D498/10 ,  C07D519/00

摘要： Compounds comprising piperazines, piperidines, spiro-furanopiperidines, and analogs thereof are provided that are modulators, such as positive allosteric modulators, of one or more subclasses of vasopressin receptors. The compounds can be selective modulators of one or more subclasses of vasopressin receptors. Compounds of the invention can be used in the treatment of a condition wherein modulating a vasopressin receptor is medically indicated for treatment of the condition.