专利检索 ap:("SCRIPPS RESEARCH INST") AND inv:"LIU WENSHE" 第 1 页

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发明公开
GENETIC INCORPORATION OF UNNATURAL AMINO ACIDS INTO PROTEINS IN MAMMALIAN CELLS 审中-公开
标题翻译：遗传安装非天然氨基酸插入在哺乳动物细胞中的蛋白质

公开(公告)号：EP2069481A4

公开(公告)日：2010-01-06

申请号：EP07870795

申请日：2007-10-17

申请人： SCRIPPS RESEARCH INST

发明人： LIU WENSHE , SCHULTZ PETER G

IPC分类号： C12N5/10 , C12N5/16 , C12N5/18 , C12P21/04

CPC分类号： C12N9/93 , C12P21/02

摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins in mammalian host cells, for example, primate host cells and rodent host cells. The invention provides, for example but not limited to, translation systems that include host cells (e.g., primate or rodent cells), orthogonal aminoacyl-tRNA synthetases derived from eubacterial synthetases, orthogonal tRNAs, and the unnatural amino acid. The invention also relates to methods for producing proteins of interest comprising at least one unnatural amino acid in mammalian host cell systems.