专利检索 ap:("SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES") AND inv:"NISHIMURA, Hiroaki c/o Tsumura & Co." 第 1 页

1.

发明授权
HUPERZINE A DERIVATIVES, THEIR PREPARATION AND THEIR USE 失效
标题翻译：石杉碱甲衍生物，其生产和使用

公开(公告)号：EP0806416B1

公开(公告)日：2003-05-07

申请号：EP95941572.0

申请日：1995-12-26

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： ZHU, Dayuan , TANG, Xican , LIN, Jinlai , ZHU, Cheng , SHEN, Jingkang , WU, Guansong , JIANG, Shanhao , YAMAGUCHI, Takuji c/o Tsumura & Co. , TANAKA, Kazuhiro , WAKANATSU, Takeshi c/o Tsumura & Co. , NISHIMURA, Hiroaki c/o Tsumura & Co.

IPC分类号： C07D221/22 , C07D401/06 , C07D401/12 , A61K31/44

CPC分类号： C07D401/06 , C07D221/22 , C07D401/12 , C07D401/14 , C07D405/12

摘要： The present invention relates to novel huperzine A derivatives of formula (II), wherein Y is (a), or R' and Y together form =CH; R is (C1-C5)alkyl, (b), (c), (d), wherein n is 0 or 1, X is H, (C1-C5)alkyl; (C1-C5)alkyloxy; nitro, halogen, carboxy, alkyloxycarbonyl, hydroxymethyl, hydroxy, amino substituted by bis -(C1-C5)alkyl; -(CH2mCOOZ, wherein m=0∩5, Z is H or (C1-C5)alkyl; -CH=CH-G, wherein G is phenyl, furanyl, carboxy, alkyloxycarbonyl; and dihydro- or tetrahydro-pyridyl1 substituted by (C1-C5)alkyl at the nitrogen atom; R' is H, (C1-C5)alkyl, pyridoyl, benzoyl substituted by (C1-C5)alkyloxy; R' is H or (C1-C5)alkyl; processes for their manufacture and their use as acetyl cholinesterase inhibitor.