公开(公告)号：EP2255816A1

公开(公告)日：2010-12-01

申请号：EP09708356.2

申请日：2009-01-14

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES ,  The Garvan Institute Of Medical Research, Australia

发明人： YE, Yang ,  JAMES, David, E ,  TAN, Minjia ,  COONEY, Gregory, J ,  KE, Changqiang ,  KRAEGEN, Edward, W ,  CHEN, Tong ,  YE, Jiming ,  LI, Xiqiang

IPC分类号： A61K31/704 ,  A61K31/575 ,  A61P3/04 ,  A61P3/10

CPC分类号： A61K31/575 ,  A61K31/704

摘要： The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation of medications for prevention and treatment of diabetes and obesity. The above cucurbitane triterpenoids may be acted as a glucose uptake stimulator, an agonist for the translocation of glucose transporter 4(GLUT4) to the cell membrane, and an activator of adenosine monophosphate-activated protein kinase (AMPK). They may have potential for the prevention and treatment of diabetes and obesity.

摘要翻译： 本发明游离缺失盘医疗使用由下式表示，并从葫芦科的苦瓜在药物用于预防和治疗糖尿病和肥胖的制备中分离葫芦三萜类化合物。 上述葫芦三萜类化合物可以充当葡萄糖摄取刺激物，以激动剂葡萄糖转运蛋白4（GLUT4）与细胞膜易位，以及磷酸腺苷活化蛋白激酶的激活剂（AMPK）。 他们可能有糖尿病和肥胖的预防和治疗潜力。

公开(公告)号：EP2255816B1

公开(公告)日：2016-03-30

申请号：EP09708356.2

申请日：2009-01-14

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES ,  The Garvan Institute Of Medical Research, Australia

发明人： YE, Yang ,  JAMES, David, E ,  TAN, Minjia ,  COONEY, Gregory, J ,  KE, Changqiang ,  KRAEGEN, Edward, W ,  CHEN, Tong ,  YE, Jiming ,  LI, Xiqiang

IPC分类号： A61K31/704 ,  A61K31/575 ,  A61P3/04 ,  A61P3/10

CPC分类号： A61K31/575 ,  A61K31/704