公开(公告)号：EP2893924A4

公开(公告)日：2016-04-20

申请号：EP13836159

申请日：2013-09-03

申请人： SHIMADZU CORP ,  UNIV KYOTO

发明人： HARA ISAO ,  OZEKI EIICHI ,  KIMURA SHUNSAKU ,  MAKINO AKIRA

IPC分类号： A61K49/00 ,  A61K9/10 ,  A61K9/51 ,  A61K47/48

CPC分类号： A61K49/0054 ,  A61K9/5153 ,  A61K47/50 ,  A61K47/51 ,  A61K47/593 ,  A61K49/0034 ,  A61K49/0089 ,  A61K49/12 ,  A61K49/124 ,  A61K51/0404 ,  A61K51/06

摘要： The present invention provides a molecular assembly whose retention time in a target site is adjusted depending on the kind or purpose of a labeling agent or drug encapsulated therein, and a molecular assembly that can suppress the ABC phenomenon and that can be administered more than once within a short span. A molecular assembly comprising: a branched-type amphiphilic block polymer A comprising a branched hydrophilic block comprising sarcosine and a hydrophobic block comprising a polylactic acid chain; and a functional substance F comprising a functional site and a polylactic acid chain, wherein the polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises L-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises D-lactic acid units, or the Polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises D-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises L-lactic acid units.

公开(公告)号：EP2725053A4

公开(公告)日：2014-10-29

申请号：EP12802877

申请日：2012-06-22

申请人： SHIMADZU CORP ,  UNIV KYOTO

发明人： OZEKI EIICHI ,  KIMURA SHUNSAKU ,  MAKINO AKIRA

IPC分类号： C08G81/00 ,  A61K9/10 ,  A61K9/51 ,  A61K47/34 ,  A61K49/00 ,  A61K51/06 ,  B82Y5/00 ,  C08G83/00 ,  C08L67/04

CPC分类号： A61K49/0054 ,  A61K9/1075 ,  A61K9/5153 ,  A61K47/34 ,  A61K47/641 ,  A61K49/0002 ,  A61K49/0034 ,  A61K49/0082 ,  A61K49/124 ,  B82Y40/00 ,  C08G69/44 ,  C08G83/005 ,  C08G83/008 ,  C08L101/005 ,  Y10S424/16 ,  Y10T428/2982

公开(公告)号：EP2305214A4

公开(公告)日：2013-07-10

申请号：EP09758388

申请日：2009-06-04

申请人： SHIMADZU CORP

发明人： HARA ISAO ,  YAMAHARA RYO ,  OZEKI EIICHI ,  TAKEUCHI ERI ,  KIMURA SHUNSAKU ,  KONDOH SHINAE ,  MAKINO AKIRA ,  YAMAMOTO FUMIHIKO

IPC分类号： A61K9/10 ,  A61K9/127 ,  A61K9/19 ,  A61K47/34 ,  A61K47/42 ,  A61K47/48 ,  A61K49/00 ,  A61K51/00 ,  A61P35/00

CPC分类号： A61K51/06 ,  A61K9/5153 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0054 ,  A61K49/0082 ,  A61K51/1234

摘要： The present invention provides a molecular assembly which is less likely to accumulate in tissue other than cancer tissue, is highly safe for a living body, and can be prepared by a simple and safe method and whose particle size can be easily controlled. The present invention provides a molecular imaging system and a molecular probe useful for the system, and a drug delivery system and a molecular probe useful for the system. The present invention provides a method for preparing molecular assembly, by which the particle size of molecular assembly having a signal group or a drug can be arbitrarily controlled in order to allow the molecular assembly to effectively accumulate in cancer tissue by utilizing EPR effect. A molecular assembly comprising: an amphiphilic block polymer A comprising a hydrophilic block chain and a hydrophobic block chain having 10 or more lactic acid units; a hydrophobic polymer A2 having at least 10 or more lactic acid units; and/or a labeled polymer B comprising at least 10 or more lactic acid units and a labeling group.