公开(公告)号：EP1988077A4

公开(公告)日：2009-09-02

申请号：EP07714666

申请日：2007-02-21

申请人： SHIONOGI & CO

发明人： MASUI MORIYASU ,  ADACHI MAKOTO ,  MIKAMIYAMA HIDENORI ,  MATSUMURA AKIRA ,  TSUNO NAOKI

IPC分类号： C07D209/08 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/538 ,  A61P25/02 ,  A61P25/04 ,  A61P25/14 ,  A61P25/18 ,  A61P39/00 ,  A61P43/00 ,  C07D209/34 ,  C07D215/38 ,  C07D235/08 ,  C07D235/26 ,  C07D249/18 ,  C07D263/58 ,  C07D277/68 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04

CPC分类号： C07D209/08 ,  C07D209/34 ,  C07D215/38 ,  C07D235/08 ,  C07D235/26 ,  C07D249/18 ,  C07D263/58 ,  C07D277/68 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04

摘要： Nitrogenous heterocyclic derivatives represented by the general formula (I) which each bind specifically to NR1/NR2B receptor and are useful as NR2B receptor antagonists (particularly analgesic for cancer pain or neuroprotectant); pharmaceutically acceptable salts thereof; or solvates of both: (I) wherein Z is N or CR 1 ; A 1 is a (substituted) nitrogenous aromatic mono- or fused-cyclic group having -NH- in the ring; A 2 is a (substituted) aromatic carbocyclic group or a (substituted) aromatic heterocyclic group; R 1 and R 2 are each independently hydrogen, hydroxy, or the like; R a , R b , R c and R d are each independently hydrogen or lower alkyl; w is 2 or 3; t is 1 or 2; X is -CONR 5 (CR 3 R 4 )n-, -NR 5 CO(CR 3 R 4 )n-, -NR 5 COCO(CR 3 R 4 )n-, -(CR 3 R 4 )mCONR 5 -, or the like; m is 1 to 4; n is 0 to 4; R 3 and R 4 are each independently hydrogen, halogeno, hydroxyl, or the like; and R 5 's are each independently hydrogen or lower alkyl.

公开(公告)号：EP2040698A4

公开(公告)日：2011-08-10

申请号：EP07810356

申请日：2007-07-12

申请人： SHIONOGI & CO ,  PURDUE PHARMA LP

发明人： MATSUMURA AKIRA ,  MIKAMIYAMA HIDENORI ,  TSUNO NAOKI ,  KYLE DONALD J ,  SHAO BIN ,  YAO JIANGCHAO

IPC分类号： A61K31/40 ,  C07D207/14 ,  C07D211/72 ,  C07D211/96 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04

CPC分类号： C07D211/72 ,  C07D211/96 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04

公开(公告)号：EP2164325A4

公开(公告)日：2011-09-14

申请号：EP08767992

申请日：2008-05-30

申请人： SHIONOGI & CO

发明人： TSUNO NAOKI ,  MIKAMIYAMA HIDENORI ,  MASUI MORIYASU

IPC分类号： A01N43/40 ,  A61K31/445 ,  A61P25/00

CPC分类号： C07D211/96