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1.发明公开PROCESS FOR PRODUCING MEDICINAL COMPOSITION OF BASIC HYDROPHOBIC MEDICINAL COMPOUND 有权PROCESS碱性疏水活性药物的制备
公开(公告)号：EP1172097A1
公开(公告)日：2002-01-16
申请号：EP00915360.2
申请日：2000-04-06
申请人： SHIONOGI & CO., LTD.
发明人： SHODAI, Hidekazu, Shionogi & Co., Ltd. , NAGAFUJI, Noboru, Shionogi & Co., Ltd. , MATSUDA, Shuichi, Shionogi & Co., Ltd. , SUZUKI, Yusuke, Shionogi & Co., Ltd.
IPC分类号： A61K9/00
CPC分类号： A61K9/1688
摘要： The present invention provides a method for preparation of a pharmaceutical composition which comprises suspending a hydrophobic medical compound without generating foams.
The present inventors have directed attention to properties of a hydrophobic medical compound and found a method for preparation of a pharmaceutical composition which comprises suspending and dispersing a basic hydrophobic medical compound, and neutralizing with a basic aqueous solution.摘要翻译： 本发明提供了一种制剂，其包含悬浮，而不会产生泡沫的疏水性医疗化合物的药物组合物的方法。 本发明人把注意力转向的疏水性医疗化合物的性质，并发现为制剂，其包含悬浮和碱性疏水医疗化合物分散，并用碱性溶液wässrige中和的药物组合物的方法。
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2.发明授权PROCESS FOR PRODUCING MEDICINAL COMPOSITION OF A BASIC HYDROPHOBIC MEDICINAL COMPOUND 有权PROCESS碱性疏水活性药物的制备
公开(公告)号：EP1172097B1
公开(公告)日：2004-09-08
申请号：EP00915360.2
申请日：2000-04-06
申请人： SHIONOGI & CO., LTD.
发明人： SHODAI, Hidekazu, Shionogi & Co., Ltd. , NAGAFUJI, Noboru, Shionogi & Co., Ltd. , MATSUDA, Shuichi, Shionogi & Co., Ltd. , SUZUKI, Yusuke, Shionogi & Co., Ltd.
CPC分类号： A61K9/1688
摘要： A process for producing a medicinal composition characterized by suspending a hydrophobic medicinal compound without foaming. The above process is characterized by noting the nature of a basic hydrophobic medicinal compound, suspending and dispersing the compound in an acidic aqueous solution and then neutralizing with a basic aqueous solution.
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