公开(公告)号：EP0131921A2

公开(公告)日：1985-01-23

申请号：EP84108218.3

申请日：1984-07-12

申请人： SHIONOGI & CO., LTD.

发明人： Sugasawa, Tsutomo ,  Sasakura, Kazuyuki

IPC分类号： C07D211/18 ,  C07D207/14 ,  C07C119/14

CPC分类号： C07D211/58 ,  C07D207/14 ,  C07D209/08

摘要： Novel ortho-(mono-substituted amino) phenylimines being intermediates to psychotropic drugs and other drugs are economically and industrially prepared by reacting anilines with nitriles in the presence of a boron tri-fluoride ether adduct and a halide-type Lewis acid, if necessary together with an organic base. Furthermore, the imines can be hydrolyzed with an acid to afford the corresponding ketones.

公开(公告)号：EP0131921B1

公开(公告)日：1988-07-06

申请号：EP84108218.3

申请日：1984-07-12

申请人： SHIONOGI & CO., LTD.

发明人： Sugasawa, Tsutomo ,  Sasakura, Kazuyuki

IPC分类号： C07D211/18 ,  C07D207/14 ,  C07C119/14

CPC分类号： C07D211/58 ,  C07D207/14 ,  C07D209/08

公开(公告)号：EP0131921A3

公开(公告)日：1985-03-06

申请号：EP84108218

申请日：1984-07-12

申请人： SHIONOGI & CO., LTD.

发明人： Sugasawa, Tsutomo ,  Sasakura, Kazuyuki

IPC分类号： C07D211/18 ,  C07D207/14 ,  C07C119/14

CPC分类号： C07D211/58 ,  C07D207/14 ,  C07D209/08

摘要： Novel ortho-(mono-substituted amino) phenylimines being intermediates to psychotropic drugs and other drugs are economically and industrially prepared by reacting anilines with nitriles in the presence of a boron tri-fluoride ether adduct and a halide-type Lewis acid, if necessary together with an organic base. Furthermore, the imines can be hydrolyzed with an acid to afford the corresponding ketones.