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    Carbamoylpyrrolidone derivatives, their use and preparation
    2.
    发明公开
    Carbamoylpyrrolidone derivatives, their use and preparation 失效
    氨基甲酰基吡咯烷酮，我是Verwendung und Herstellung。

    公开(公告)号：EP0304330A1

    公开(公告)日：1989-02-22

    申请号：EP88307723.2

    申请日：1988-08-19

    申请人： SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

    发明人： Matsumura, Hiromu ,  Matsushita, Akira ,  Yano, Toshisada ,  Eigyo, Masami

    IPC分类号： C07D207/27 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/395

    CPC分类号： C07D207/27 ,  C07D401/12 ,  C07D403/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/10

    摘要： Compounds of the formula:
    (wherein R is phenoxy optionally substituted by a halogen, methoxy, or methyl group,
    one of A and B is
    and the other is
    R 1 is hydrogen or C 1 -C 5 alkyl;

    Z 1 is phenyl, benzyl. or isoxazolyl each optionally substituted by a halogen, methoxy, or methyl group; Z 2 is hydrogen, C 1 -C 5 alkyl, C 2 -C 5 alkenyl, or phenyl optionally mono-, di-, or tri-substituted by a halogen, methoxy, or methyl group; or Z 1 and Z 2 taken together with the adjacent nitrogen atom may form 5-membered heterocyclic group: Z 3 is Ci-C 5 hydroxyalkyl, di(C 1 -C 5 alkyl)sulfamoyl, 6-membered heterocyclic group, phenyl, benzyl, or phenylsulfonyl each phenyl moiety of the last three members being optionally substituted by a halogen, methoxy, or methyl group: Z 4 is phenyl optionally substituted by a halogen, methoxy, or methyl group or 5- or 6-membered heterocyclic group which is optionally substituted by a halogen, methoxy, or methyl group and which can be optionally condensed with a benzene ring; Z 5 is thienyl or phenyl each optionally substituted by a halogen, methoxy, or methyl group; Z 6 is thienyl or phenyl each optionally substituted by a halogen, methoxy, or methyl group; m is an integer from 0 to 2; n is an integer from 2 to 3), and their acid addition salts may be useful as drugs for senile dementia, or as psychotropic, or antiamnesia agents.

    摘要翻译： 下式的化合物：其中R是任选被卤素，甲氧基或甲基取代的苯氧基，A和B之一的CHEM是CHEM，另一个是CHEM R 1是氢 或C 1 -C 5烷基; Z 1是各自任选被卤素，甲氧基或甲基取代的苯基，苄基或异恶唑基; Z 2是氢，C 1 -C 5烷基，C 2 -C 5烯基或任选的苯基 被卤素，甲氧基或甲基单取代，二取代或三取代;或与相邻氮原子一起使用的Z 1和Z 2可以形成5元杂环基; Z 3为 C1-C5羟基烷基，二（C1-C5烷基）氨磺酰基，6元杂环基，苯基，苄基或苯基磺酰基，最后三个成员的每个苯基部分任选被卤素，甲氧基或甲基取代; Z 4 是任选被卤素，甲氧基或甲基取代的苯基或任选被卤素，甲氧基或甲基取代的5-或6-元杂环基，其可以是任选的 与苯环稠合; Z 5是噻吩基或各自任选被卤素，甲氧基或甲基取代的苯基; Z 6是任选被卤素，甲氧基或甲基取代的噻吩基或苯基; m为0〜2的整数; n为2至3的整数），并且它们的酸加成盐可用作老年痴呆的药物，或作为精神药物或抗遗忘因子。