公开(公告)号：EP3406733A1

公开(公告)日：2018-11-28

申请号：EP17172639.1

申请日：2017-05-24

申请人： SIB Swiss Institute of Bioinformatics ,  Centre Hospitalier Universitaire Vaudois (CHUV) ,  Université de Lausanne ,  Ludwig Institute for Cancer Research Ltd

发明人： MICHIELIN, Olivier ,  ZOETE, Vincent ,  COUKOS, George ,  IRVING, Melita ,  DILEK, Nahzli ,  REICHENBACH, Patrick ,  ASCENCAO, Kelly

IPC分类号： C12Q1/48 ,  C12N9/12

CPC分类号： C12Q1/485 ,  A61K38/43 ,  C12N9/1205

摘要： The present invention relates to methods of designing kinase mutants for reprogramming the sensitivity of a target kinase to some specific inhibitors, methods of reprogramming the sensitivity of a target kinase to some specific inhibitors, wherein those kinase inhibitors have little or no affinity for the wild-type target kinase, vectors or cells expressing said mutated kinases, composition and uses thereof for the prevention and/or treatment of a disease or disorder, in particular cancer.

公开(公告)号：EP3630998A1

公开(公告)日：2020-04-08

申请号：EP18727003.8

申请日：2018-05-24

申请人： SIB Swiss Institute of Bioinformatics ,  Centre Hospitalier Universitaire Vaudois (CHUV) ,  Université de Lausanne ,  Ludwig Institute for Cancer Research Ltd

发明人： MICHIELIN, Olivier ,  ZOETE, Vincent ,  COUKOS, George ,  IRVING, Melita ,  DILEK, Nahzli ,  REICHENBACH, Patrick ,  ASCENCAO, Kelly

IPC分类号： C12Q1/48 ,  C12N9/12