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    METHOD FOR BIO-COMPUTER ANALYSIS FOR EVALUATING THE RISK FOR THE ONSET OF AGE- RELATED MACULAR DEGENERATION
    1.
    发明公开
    METHOD FOR BIO-COMPUTER ANALYSIS FOR EVALUATING THE RISK FOR THE ONSET OF AGE- RELATED MACULAR DEGENERATION 审中-公开

    公开(公告)号：EP3519590A1

    公开(公告)日：2019-08-07

    申请号：EP17791158.3

    申请日：2017-09-29

    申请人： SIFI S.p.A.

    发明人： SPATA, Massimo ,  BLANCO, Anna Rita ,  CONOCI, Sabrina ,  CURATOLO, Maria Cristina

    IPC分类号： C12Q1/68

    摘要： The present invention relates to a method for estimating the risk factor (HR) for the onset of macular degeneration in a subject, which method comprises the evaluation of a first series of genetic parameters comprising at least the genetic loci R1210C in CFH, variants in COL8A1 and RAD51 B, and the evaluation of a second series of environmental, individual and/or clinical parameters. This method is characterized in that said risk factor (HR) is calculated by assigning a greater importance to said evaluation of the first series of genetic parameters with respect to said evaluation of the second series of environmental, individual and/or clinical parameters. The method of the present invention thus allows to estimate the genetic risk of AMD more accurately than the methods known in the art.