公开(公告)号：EP1060245A2

公开(公告)日：2000-12-20

申请号：EP99912239.3

申请日：1999-03-02

申请人： SIGNAL PHARMACEUTICALS, INC.

发明人： LI, Ronghao ,  SAH, Dinah, W., Y.

IPC分类号： C12N5/10 ,  C12Q1/00

CPC分类号： C12N5/0623 ,  C12N2503/00 ,  C12N2510/04

摘要： Conditionally-immortalized human spinal cord cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons, including motoneurons. The cell lines and/or differentiated cells may be used for the development of therapeutic agents to prevent and treat a variety of spinal cord-related diseases and injuries. The cell lines and/or differentiated cells may also be used in assays and for the general study of spinal cord cell development and differentiation.

公开(公告)号：EP0925357A1

公开(公告)日：1999-06-30

申请号：EP97941398.0

申请日：1997-09-02

申请人： SIGNAL PHARMACEUTICALS, INC.

发明人： SAH, Dinah, W., Y. ,  GAGE, Fred, H. ,  RAY, Jasodhara

IPC分类号： G01N33 ,  A61K45 ,  A61P25 ,  C12N5 ,  C12N15 ,  C12Q1 ,  A61K48

CPC分类号： C12N5/0623 ,  A61K48/00 ,  C12N2501/11 ,  C12N2501/13 ,  C12N2501/135

摘要： Conditionally-immortalized human CNS progenitor cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons and/or astrocytes. Such cell lines and/or differentiated cells may be used for the development of therapeutic agents to prevent and treat a variety of CNS-related diseases. Such cell lines and/or differentiated cells may also be used in assays and for the general study of CNS cell development, death and abnormalities.

摘要翻译： 提供了有条件永生化的人CNS祖细胞系。 这种可能是克隆的细胞系可用于产生神经元和/或星形胶质细胞。 这种细胞系和/或分化的细胞可用于开发治疗剂以预防和治疗多种CNS相关疾病。 这样的细胞系和/或分化的细胞也可以用于测定和用于CNS细胞发育，死亡和异常的一般研究。