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1.发明公开Combined vaccines comprising Hepatitis B surface antigen and other antigens 失效Kombinierte Impfstoffe，死亡乙型肝炎抗原抗原
公开(公告)号：EP0835663A2
公开(公告)日：1998-04-15
申请号：EP97204034.9
申请日：1993-05-15
发明人： Petre, Jean, SmithKline Beecham Biologicals S.A , Hauser, Pierre, SmithKline Beecham Biologicals s.a
IPC分类号： A61K39/295 , A61K39/39
CPC分类号： A61K39/292 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/099 , A61K39/12 , A61K39/39 , A61K2039/55505 , A61K2039/70 , C12N2730/10134 , C12N2770/32434 , Y02A50/464 , Y02A50/466
摘要： Stable and effective multivalent vaccine compositions comprising Hepatitis B surface antigen (HBsAg) are described wherein the HBsAg component is stable for one week at 37° C and is highly immunogenic, for example when the vaccine is administered to infants. The compositions typically comprise HBsAg adsorbed to aluminium phosphate and other antigens, especially those suitable for use in a paediatric vaccine, adsorbed to aluminium phosphate or aluminium hydroxide. Methods for preparing the vaccines and the use of aluminium phosphate to stabilise HBsAg in a multivalent vaccine formulation are also described.
摘要翻译： 描述包含乙型肝炎表面抗原（HBsAg）的稳定和有效的多价疫苗组合物，其中HBsAg组分在37℃下稳定一周，并且是高度免疫原性的，例如当将疫苗施用于婴儿时。 组合物通常包含吸附到磷酸铝上的HBsAg，以及吸附在磷酸铝或氢氧化铝上的适用于小儿疫苗的其它抗原。 还描述了制备疫苗的方法和使用磷酸铝来稳定多价疫苗制剂中的HBsAg。
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2.发明公开
公开(公告)号：EP0835663A3
公开(公告)日：1999-03-03
申请号：EP97204034.9
申请日：1993-05-15
发明人： Petre, Jean, SmithKline Beecham Biologicals S.A , Hauser, Pierre, SmithKline Beecham Biologicals s.a
IPC分类号： A61K39/295 , A61K39/39
CPC分类号： A61K39/292 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/099 , A61K39/12 , A61K39/39 , A61K2039/55505 , A61K2039/70 , C12N2730/10134 , C12N2770/32434 , Y02A50/464 , Y02A50/466
摘要： Stable and effective multivalent vaccine compositions comprising Hepatitis B surface antigen (HBsAg) are described wherein the HBsAg component is stable for one week at 37° C and is highly immunogenic, for example when the vaccine is administered to infants. The compositions typically comprise HBsAg adsorbed to aluminium phosphate and other antigens, especially those suitable for use in a paediatric vaccine, adsorbed to aluminium phosphate or aluminium hydroxide. Methods for preparing the vaccines and the use of aluminium phosphate to stabilise HBsAg in a multivalent vaccine formulation are also described.
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