专利检索 ap:("SMITHKLINE BEECHAM BIOLOGICALS S.A." OR "GOVERNMENT OF THE UNITED STATES OF AMERICA, as repr. by THE SECR. OF THE DEPT. OF HEALTH AND HUMAN SERVICES AND HIS SUCCESSORS") AND inv:"PURCELL, Robert H." 第 1 页

1.

发明授权
MUTANTS OF HEPATITIS A VIRUS STRAIN HM-175 FOR USE AS HEPATITIS A VACCINES 失效
标题翻译：突变体肝炎病毒株HM-175 FOR USE甲型肝炎病毒疫苗

公开(公告)号：EP0666751B1

公开(公告)日：2001-09-12

申请号：EP93921524.0

申请日：1993-09-17

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A. , GOVERNMENT OF THE UNITED STATES OF AMERICA, as repr. by THE SECR. OF THE DEPT. OF HEALTH AND HUMAN SERVICES AND HIS SUCCESSORS

发明人： FUNKHOUSER, Ann W. , EMERSON, Suzanne U. , PURCELL, Robert H. , D'HONDT, Eric

IPC分类号： C12N15/51 , C12N7/00 , C12N7/04 , A61K39/29

CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K2039/5254 , A61K2039/542 , A61K2039/545 , C12N7/00 , C12N2770/32421 , C12N2770/32422 , C12N2770/32432 , C12N2770/32434 , Y02A50/464

摘要： A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without inactivation, methods for adapting HAV to growth in MRC-5, vaccine compositions and method of vaccinating humans against HAV infection.