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1.发明授权TETRAHYDROBENZAZEPINE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE D3 RECEPTORS (ANTIPSYCHOTIC AGENTS) 有权Tetrahydrobenzazepine衍生物FOR USE多巴胺D3受体调节剂（抗焦虑剂）
公开(公告)号：EP1335915B1
公开(公告)日：2008-01-02
申请号：EP01996537.5
申请日：2001-11-12
发明人： HADLEY, Michael, Stewart, GlaxoSmithKline , LIGHTFOOT, Andrew, P., GlaxoSmithKline , MACDONALD, Gregor, James, GlaxoSmithKline , STEMP, Geoffrey, GlaxoSmithKline
IPC分类号： C07D403/12
CPC分类号： C07D223/16 , A61K31/55 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04
摘要： The invention provides compounds of formula (I), wherein R1-R4, A, B and t are as defined in claim 1. The compounds are modulators of dopamine D¿3? receptors and have potential in the treatment of psychotic conditions (e.g. schizophrenia) or substance abuse.
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2.发明授权GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS 有权体GlyT1转运蛋白抑制剂及它们在神经系统和疾病的治疗NEUROPSYCHIATISCHEN
公开(公告)号：EP1455777B1
公开(公告)日：2007-11-21
申请号：EP02788198.6
申请日：2002-12-19
发明人： COULTON, Steven, GlaxoSmithKline , HADLEY, Michael, Stewart, GlaxoSmithKline , HERDON, Hugh, Jonathan, GlaxoSmithKline , JIN, Jian, GlaxoSmithKline , JOINER, Graham, J., GlaxoSmithKline , PORTER, Roderick, Alan, GlaxoSmithKline , RAHMAN, Shahzad, Sharooq, GlaxoSmithKline
IPC分类号： A61K31/33 , C07D295/12 , C07D207/06 , C07D209/44 , C07D215/06 , C07D223/04 , C07D333/34 , C07D311/70 , C07D285/14 , C07D271/12 , C07D333/62 , C07D513/04 , A61P25/18 , A61P25/28
CPC分类号： C07D333/62 , A61K31/33 , C07D207/06 , C07D209/02 , C07D209/44 , C07D215/06 , C07D215/36 , C07D217/02 , C07D217/04 , C07D271/12 , C07D295/13 , C07D311/70 , C07D333/34 , C07D513/04
摘要： The present invention relates to glycine transporter inhibiting compounds of formula (I): for the manufacture of a medicament for treating disorders mediated GlyT1, wherein R1-R9 are as in the description.
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