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1.发明授权A method of preparing a composition containing a high proportion of ganglioside 失效一种制备组合物的具有高Gangliosidanteil过程
公开(公告)号：EP0816374B1
公开(公告)日：2009-03-04
申请号：EP97106809.3
申请日：1997-04-24
CPC分类号： A23L2/00 , A23L33/105
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2.发明授权
公开(公告)号：EP0665287B1
公开(公告)日：2000-03-29
申请号：EP95101137.8
申请日：1995-01-27
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3.发明公开Glycophospholipid and process for preparation thereof 失效Glycophospholipid和Verfahren zu dessen Herstellung。
公开(公告)号：EP0684252A1
公开(公告)日：1995-11-29
申请号：EP95107426.9
申请日：1995-05-16
发明人： Shiota, Makoto , Hanagata, Goro , Tatsumi, Kiyoshi
IPC分类号： C07H15/12
CPC分类号： C07H15/12
摘要： The present invention relates to glycophospholipids represented by the general formula [I]:
The glycophospholipid of the present invention can be obtained by extracting lipid fraction of whey, butter milk, etc. with a mixed solvent of chloroform/methanol and purifying by silica gel chromatography.
The glycophospholipid of the present invention is that having a novel structure and existing in milk lipid, and utilized as a biochemical reagent, a starting material for medicine and foodstuff or a surfactant.摘要翻译： 本发明涉及由通式[I]表示的糖磷脂：
本发明的糖磷脂可以通过用氯仿/甲醇的混合溶剂提取乳清，奶油等的脂质分数，并通过 硅胶色谱法。 本发明的糖磷脂具有新颖的结构并且存在于乳脂中，用作生物化学试剂，用于药物和食品的起始材料或表面活性剂。 -
公开(公告)号：EP0713879B1
公开(公告)日：1998-12-02
申请号：EP95115469.9
申请日：1995-09-29
发明人： Hanagata, Goro , Miura, Susumu , Tatsumi, Kiyoshi
IPC分类号： C07H3/06
CPC分类号： C07H15/10
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公开(公告)号：EP0713879A1
公开(公告)日：1996-05-29
申请号：EP95115469.9
申请日：1995-09-29
发明人： Hanagata, Goro , Miura, Susumu , Tatsumi, Kiyoshi
IPC分类号： C07H3/06
CPC分类号： C07H15/10
摘要： A method of preparing Ganglioside G M3 which comprises converting Ganglioside G D3 into Ganglioside G M3 in an alkaline condition is disclosed. The conversion of Ganglioside G D3 into Ganglioside G M3 is preferably carried out by thermal treating Ganglioside G D3 in an alkaline condition. The thermal treatment is preferably carried out at a pH ranging from 8 to 11 and at a temperature ranging from 30° C to 140° C.
摘要翻译： 公开了一种制备神经节苷脂GM3的方法，其包括在碱性条件下将神经节苷脂GD3转化为神经节苷脂GM3。 神经节苷脂GD3转化为神经节苷脂GM3优选通过在碱性条件下热处理神经节苷脂GD3进行。 热处理优选在8至11的pH和30℃至140℃的温度下进行。
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公开(公告)号：EP0711782A1
公开(公告)日：1996-05-15
申请号：EP95115468.1
申请日：1995-09-29
发明人： Hanagata, Goro , Miura, Susumu , Tatsumi, Kiyoshi
IPC分类号： C07H3/06
CPC分类号： C07H15/10
摘要： A method of preparing Ganglioside G M3 which comprises converting Ganglioside G D3 included in a raw material containing lipids into Ganglioside G M3 in situ is disclosed. The conversion of Ganglioside G D3 into Ganglioside G M3 is preferably carried out by thermal treating the raw material at a neutral pH zone ranging from 6 to 8 and at a temperature ranging from 60°C to 140°C. The raw material containing lipids preferably contains 10 wt% or more per solids of lipids.
摘要翻译： 公开了一种制备神经节苷脂GM3的方法，该方法包括将包含在含有脂质的原料中的神经节苷脂GD3原位转化为神经节苷脂GM3。 神经节苷脂GD3向神经节苷脂GM3的转化优选通过在6-8的中性pH区域和60-140℃的温度下对原料进行热处理来进行。 含有脂质的原料优选含有每固体10重量％以上的脂质。
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7.发明公开A method of preparing a composition containing a high proportion of ganglioside 失效Verfahren zur Herstellung einer Zubereitung mit hohem Gangliosidanteil
公开(公告)号：EP0816374A3
公开(公告)日：2001-03-21
申请号：EP97106809.3
申请日：1997-04-24
CPC分类号： A23L2/00 , A23L33/105
摘要： A method of preparing a composition containing a high proportion of Ganglioside which comprises the steps of: (1) adding ethanol to a material containing Ganglioside so as to have a concentration of ethanol of 30 to 70 volume % and recovering the precipitated fraction containing Ganglioside; (2) adding ethanol to the recovered fraction containing Ganglioside so as to have a concentration of ethanol of 70 to 90 volume % and removing the precipitated proteins; and, (3) passing the fraction containing Ganglioside from which the proteins have been removed, through a membrane and recovering the Ganglioside retained on the membrane.
摘要翻译： 一种制备含有高比例神经节苷脂的组合物的方法，包括以下步骤：（1）向含有神经节苷脂的物质中加入乙醇使乙醇浓度为30〜70体积％，回收含有神经节苷脂的沉淀级分; （2）向含有神经节苷脂的回收部分中加入乙醇，使乙醇浓度为70〜90体积％，除去沉淀的蛋白质; 和（3）通过膜通过含有去除蛋白质的神经节苷脂的部分，并回收保留在膜上的神经节苷脂。
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公开(公告)号：EP0684252B1
公开(公告)日：2000-10-18
申请号：EP95107426.9
申请日：1995-05-16
发明人： Shiota, Makoto , Hanagata, Goro , Tatsumi, Kiyoshi
IPC分类号： C07H15/12
CPC分类号： C07H15/12
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公开(公告)号：EP0730033A3
公开(公告)日：1998-03-11
申请号：EP96102907.1
申请日：1996-02-27
摘要： A method of producing a glycosphingolipid by reacting glycosidase with oligosaccharide comprising two or more saccharide or a glycoside and ceramide as substrates and transferring saccharide residue to ceramide through transglycosylation. By simple operations, a highly pure glycosphingolipid can be obtained with little byproduct.
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公开(公告)号：EP0730033A2
公开(公告)日：1996-09-04
申请号：EP96102907.1
申请日：1996-02-27
摘要： A method of producing a glycosphingolipid by reacting glycosidase with oligosaccharide comprising two or more saccharide or a glycoside and ceramide as substrates and transferring saccharide residue to ceramide through transglycosylation. By simple operations, a highly pure glycosphingolipid can be obtained with little byproduct.
摘要翻译： 通过糖苷酶与包含两种或多种糖或糖苷和神经酰胺作为底物的寡糖反应制备糖鞘醇的方法，并通过反式糖基化将糖残基转移到神经酰胺。 通过简单的操作，可以获得极少量副产物的高纯度的鞘糖脂。
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