公开(公告)号：EP2377558A2

公开(公告)日：2011-10-19

申请号：EP10729320.1

申请日：2010-01-07

申请人： SNU R&DB Foundation

发明人： OH, Jang Hee ,  JUNG, Ji-Yong ,  LEE, Dong Hun ,  LEE, Serah ,  KIM, Yeon Kyung ,  SHIN, Jeong-eun ,  LEE, June Hyunkyung ,  CHUNG, Jin Ho

IPC分类号： A61K48/00 ,  A61K31/7105 ,  A61P17/06 ,  A61K9/06

CPC分类号： A61K36/76 ,  A61K8/06 ,  A61K8/60 ,  A61K8/97 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/107 ,  A61K9/2059 ,  A61K36/07 ,  A61K36/254 ,  A61K36/258 ,  A61K36/28 ,  A61K36/539 ,  A61K39/0005 ,  A61K47/26 ,  A61Q19/08 ,  C12N15/1137 ,  C12N2310/14 ,  C12Y204/01041

摘要： The present invention relates to a composition for improving inflammatory disease, and more specifically to a composition for improving inflammatory disease able to improve inflammatory reactions and the barrier function of epithelial tissue such as the skin, to enhance aging resistance and skin elasticity and to prevent or treat aging. The present invention makes it possible to control inflammatory reactions by modulating the expression and modulating the activity of ABH antigens, and thus the composition of the present invention can be employed as a development marker for therapeutic agents designed to soothe or treat or help in the treatment of disease caused by inflammatory reaction in body tissue and notably the skin expressed by ABH antigens, and can be used in the development of external preparations and cosmetics containing external preparations designed for the purposes such as restoration of normal function and moisturization, wrinkle enhancement, whitening and elasticity recovery in skin through modulation of differentiation of keratinocytes and the skin barrier function.

摘要翻译： 本发明涉及一种改善炎症性疾病的组合物，更具体地说，涉及一种能够改善炎性反应的组合物，其能够改善上皮组织如皮肤的炎症反应和屏障功能，以增强抗老化性和皮肤弹性，并防止或 治疗老化。 本发明使得可以通过调节表达和调节ABH抗原的活性来控制炎症反应，因此本发明的组合物可用作治疗剂的开发标记物，其用于治疗或治疗或帮助治疗 由身体组织炎症反应引起的疾病，特别是由ABH抗原表达的皮肤引起的疾病，可用于开发外用制剂和含有外用制剂的化妆品，其设计用于恢复正常功能和保湿，增皱，增白 并通过调节角质形成细胞的分化和皮肤屏障功能来恢复皮肤弹性。