公开(公告)号：EP1928489A2

公开(公告)日：2008-06-11

申请号：EP06825217.0

申请日：2006-09-27

申请人： SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： DONG, Zheng, Xin ,  CULLER, Michael, DeWitt ,  SHEN, Yeelana ,  COMSTOCK, Jeanne, Mary

IPC分类号： A61K38/22

CPC分类号： C07K14/60 ,  A61K38/00 ,  G01N2500/00 ,  Y02A50/463 ,  Y02A50/475

摘要： The invention comprises peptidyl analogs according to formulae (I) or (II) as depicted below: (R2R3)-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13- A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25- A-26-A27-A28-R1 wherein the definitions of A1 to A28 and R1 to R3 are provided for in the specification for each of formulae (I) and (II), pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising an effective amount of a compound of formula (I), that possess agonist or antagonist ghrelin activity, along with therapeutic and non-therapeutic uses thereof.

公开(公告)号：EP1624884A2

公开(公告)日：2006-02-15

申请号：EP04760052.3

申请日：2004-04-21

申请人： SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： DONG, Zheng, Xin ,  SHEN, Yeelana ,  COMSTOCK, Jeanne, Mary ,  KIM, Sun, H.

IPC分类号： A61K38/01 ,  A61K38/02 ,  A61K38/03 ,  A61K38/04 ,  A61K38/05 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K38/09 ,  A61K38/10 ,  A61K38/12 ,  A61K38/16 ,  A61K38/22 ,  A61K38/24 ,  A61K38/31 ,  C07K2/00 ,  C07K7/00 ,  C07K7/23 ,  C07K7/50 ,  C07K7/64 ,  C07K14/00

CPC分类号： C07K14/655 ,  A61K38/00 ,  A61K47/64 ,  C07K7/086 ,  C07K7/23 ,  C07K14/6555

摘要： The invention features targeted cytotoxic compounds and methods relating to their therapeutic use for the treatment of neoplasia and other conditions.