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    Method of evaluating the physiological activities and structural characteristics of medicinal substances
    1.
    发明公开
    Method of evaluating the physiological activities and structural characteristics of medicinal substances 失效
    程序的生理活动和药物结构特性的评价。

    公开(公告)号：EP0420683A2

    公开(公告)日：1991-04-03

    申请号：EP90310663.1

    申请日：1990-09-28

    申请人： SOGO PHARMACEUTICAL COMPANY LIMITED

    发明人： Okahata, Yoshio ,  Yomemori, Kazuyuki, c/o Sogo Pharma. Co. Ltd. ,  Fujita, Shinsuke, c/o Sogo Pharma. Co. Ltd.

    IPC分类号： G01N27/00 ,  G01N33/15

    CPC分类号： G01N29/036 ,  G01N33/15 ,  G01N2291/0256

    摘要： A method of evaluating the physioiogical activities and structural characteristics of medicinal substances, which method comprises determining correlations of (A) at least one of kinds of lipid films, physiological activity factors of medicinal substances and structural characteristics of medicinal substances with (B) at least one of amounts of change in frequency, adsorbed amounts or interacted amounts due to adsorption or interaction of the medicinal substances onto the lipid films and lipid film-­water partition coefficients, by use of crystal oscillators cast various lipid films respectively, wherein the lipid film-water partition coefficient is used as a parameter in the structural activity correlation technique for medicinal substances.

    摘要翻译： 评价的physioiogical活动和药用物质，该方法包括（A）确定的采矿相关种脂质膜的，药用物质，并用（B）至少的医药物质结构特征生理活性因子中的至少一个结构特征的方法 在频率变化量中的一个，吸附量或由于吸附或药用物质的相互作用走上脂质膜和脂质 - 电影 - 水分配系数的相互作用量，通过使用分别投各种脂质膜晶体振荡器，worin脂质成膜 水分配系数被用作药用物质的结构活性相关技术的参数。