公开(公告)号：EP0453054A3

公开(公告)日：1991-12-04

申请号：EP91201751.4

申请日：1986-11-24

申请人： SOLVAY (Société Anonyme)

发明人： Newman, Karel Z., Jr. ,  Gore, Thomas C. ,  Tedesco, John L. ,  Petersen, Gary R. ,  Brothers, Virginia M. ,  Files, James G. ,  Paul, Leland S. ,  Chang, Ray-Jen ,  Andrews, William H. ,  Kuhn, Irene ,  McCaman, Michael ,  Sias, Stacey R. ,  Nordgren, Robert M. ,  Dragon, Elizabeth A.

IPC分类号： C12N15/30 ,  C12N15/62 ,  C12P21/00 ,  A61K39/012

CPC分类号： C07K14/455 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/61

摘要： Purified antigenic proteins are provided which are capable of inducing in a chicken an immune response conferring protection against infection by Eimeria necatrix and/or Eimeria tenella. One protein, useful for conferring protection against E. tenella and E. necatrix, has been derived from sporocysts of E. necatrix. Monoclonal antibodies directed against the antigenic proteins have also been developed which may be used to confer upon a chicken passive immunity against coccidiosis. Further provided are nucleic acid molecules encoding the antigenic proteins as well as expression vectors containing them. Methods for producing the proteins or antigenic polypeptides having amino acid sequences included within these proteins are also provided.

公开(公告)号：EP0453055A3

公开(公告)日：1991-11-06

申请号：EP91201752.2

申请日：1986-11-24

申请人： SOLVAY (Société Anonyme)

发明人： Newman, Karl Z., Jr. ,  Gore, Thomas C. ,  Tedesco, John L. ,  Petersen, Gary R. ,  Brothers, Viriginia M. ,  Files, James G. ,  Paul, Leland S. ,  Chang, Ray-Jen ,  Andrews, William H. ,  Kuhn, Irene ,  McCaman, Michael ,  Sias, Stacey R. ,  Nordgren, Robert M. ,  Dragon, Elizabeth B.

IPC分类号： A61K39/012 ,  C12N15/30 ,  C12N15/62 ,  C12P21/00

CPC分类号： C07K14/455 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/61

摘要： Multi-component vaccines which comprises admixtures of Eimeria antigens or isotopes are disclosed.

公开(公告)号：EP0453054A2

公开(公告)日：1991-10-23

申请号：EP91201751.4

申请日：1986-11-24

申请人： SOLVAY (Société Anonyme)

发明人： Newman, Karel Z., Jr. ,  Gore, Thomas C. ,  Tedesco, John L. ,  Petersen, Gary R. ,  Brothers, Virginia M. ,  Files, James G. ,  Paul, Leland S. ,  Chang, Ray-Jen ,  Andrews, William H. ,  Kuhn, Irene ,  McCaman, Michael ,  Sias, Stacey R. ,  Nordgren, Robert M. ,  Dragon, Elizabeth A.

IPC分类号： C12N15/30 ,  C12N15/62 ,  C12P21/00 ,  A61K39/012

CPC分类号： C07K14/455 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/61

摘要： Purified antigenic proteins are provided which are capable of inducing in a chicken an immune response conferring protection against infection by Eimeria necatrix and/or Eimeria tenella. One protein, useful for conferring protection against E. tenella and E. necatrix, has been derived from sporocysts of E. necatrix.
Monoclonal antibodies directed against the antigenic proteins have also been developed which may be used to confer upon a chicken passive immunity against coccidiosis.
Further provided are nucleic acid molecules encoding the antigenic proteins as well as expression vectors containing them. Methods for producing the proteins or antigenic polypeptides having amino acid sequences included within these proteins are also provided.

摘要翻译： 提供纯化的抗原蛋白质，其能够在鸡中诱导免疫应答，从而赋予针对艾美球虫和/或柔嫩艾美耳球虫感染的保护。 一种蛋白质可用于赋予对E. tenella和E. necatrix的保护作用，它来源于E. necatrix的孢子囊。 针对抗原蛋白的单克隆抗体也已经开发出来，可以用来赋予针对球虫病的鸡被动免疫。 还提供了编码抗原蛋白的核酸分子以及含有它们的表达载体。 还提供了用于产生具有包含在这些蛋白质内的氨基酸序列的蛋白质或抗原性多肽的方法。

公开(公告)号：EP0453054B1

公开(公告)日：1996-07-03

申请号：EP91201751.4

申请日：1986-11-24

申请人： SOLVAY (Société Anonyme)

发明人： Newman, Karel Z., Jr. ,  Gore, Thomas C. ,  Tedesco, John L. ,  Petersen, Gary R. ,  Brothers, Virginia M. ,  Files, James G. ,  Paul, Leland S. ,  Chang, Ray-Jen ,  Andrews, William H. ,  Kuhn, Irene ,  McCaman, Michael ,  Sias, Stacey R. ,  Nordgren, Robert M. ,  Dragon, Elizabeth A.

IPC分类号： C12N15/30 ,  C12N15/62 ,  C12P21/00 ,  A61K39/012

CPC分类号： C07K14/455 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/61

公开(公告)号：EP0453055A2

公开(公告)日：1991-10-23

申请号：EP91201752.2

申请日：1986-11-24

申请人： SOLVAY (Société Anonyme)

发明人： Newman, Karl Z., Jr. ,  Gore, Thomas C. ,  Tedesco, John L. ,  Petersen, Gary R. ,  Brothers, Viriginia M. ,  Files, James G. ,  Paul, Leland S. ,  Chang, Ray-Jen ,  Andrews, William H. ,  Kuhn, Irene ,  McCaman, Michael ,  Sias, Stacey R. ,  Nordgren, Robert M. ,  Dragon, Elizabeth B.

IPC分类号： A61K39/012 ,  C12N15/30 ,  C12N15/62 ,  C12P21/00

CPC分类号： C07K14/455 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/61

摘要： Multi-component vaccines which comprises admixtures of Eimeria antigens or isotopes are disclosed.

摘要翻译： 包括艾美耳球虫抗原或同位素的外加剂多组分疫苗游离缺失盘。